ISSN:
1432-1041
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In a controlled clinical trial 6-azauridinetriacetate, a drug that inhibits the synthesis of pyrimidine “de novo”, had a therapeutic effect in psoriasis. The general tolerance of the drug is good. However, with the dosage of 150 mg/kg/day the leucocytes and erythrocytes of the peripheral blood may drop after 5–6 weeks, the effect depending on the dosage. 270 mg/kg/day may be administered for several weeks. 400 mg/kg/day have early therapeutic effects but cannot be administered for longer periods because of the side-effects mentioned. Only serious cases of psoriasis should be treated with this drug, as with cytostatics in general.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00420718
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