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  • ZIB Catalog
  • Articles: DFG German National Licenses  (19)
  • Polymer and Materials Science  (17)
  • Achromatopsia  (2)
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  • ZIB Catalog
  • Articles: DFG German National Licenses  (19)
Material
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 37 (1974), S. 79-117 
    ISSN: 1573-2622
    Keywords: Achromatopsia ; rod monochromatism ; nystagmus ; photophobia ; color vision tests ; ERG recovery during dark adaptation ; ERG photopic components ; scotopic components ; photopic activity in purely scotopic ERGs ; ERG as function of intensity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 39 patients suffering from congenital achromatopsia were investigated by various methods, including electroretinography, during both light and dark adaptation. This condition was typically expressed by the presence of photophobia, low visual acuity, nystagmus and various degrees of ametropia. The fundus was normal in 9 cases. Most of the other cases showed various macular or foveal abnormalities. 24 patients showed complete absence of color vision, and practically all displayed the ‘scotopic line’ in the Farnsworth Panel D-15 test. The electroretinogram (ERG) was almost always extinct in light. In the dark, in most patients the ERG displayed the scotopic mechanism solely, but some ERGs indicated subnormal photopic components either at the beginning or during all dark adaptation. This presence of photopic activity in the ERG of achromats was verified by 2 additional experiments. In one, the recovery of the positive wave of four achromats was compared on a percentage scale with that of four normal subjects and found to be similar, although the slightly faster course in achromats indicates less photopic activity than in normals. In the second, the positive amplitudes of the ERGs of 12 achromats with purely scotopic ERGs were recorded at completed dark adaptation as function of increasing stimulus intensities, all above the photopic threshold, and compared with those of 16 normal subjects. The amplitudes increased linearly with the 1.2 log intensity range in both groups, though the slope of the curve of the achromats was 1/4 that of the normals. In another experiment, the positive wave of the ERG, as elicited by light over 5 log units in the scotopic range, was found in an achromat to be of very similar shape as that of a normal, indicating scotopic acitivity to be similar in both subjects. The fact that, nevertheless, photopic components were not demonstrable in most ERGs, despite present photopic activity, can be explained by the relatively insensitive electrical method coupled with the subnormality of the retinal photopic mechanism in every achromat.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 37 (1974), S. 119-144 
    ISSN: 1573-2622
    Keywords: Achromatopsia ; visual threshold ; dark adaptation ; photopic and scotopic mechanisms ; spectral luminous efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In three of the five achromats examined psychophysically, evidence of three plateaux was found at certain areas of the retina during the normally photopic phase of dark adaptation while the scotopic plateau was normal. These high intensity plateaux coincided fairly well with the photopic phase of our standard dark adaptation curve and the fourth plateau with its scotopic phase. This points to three photopic submodalities and to a normal scotopic mechanism in these achromats. However, the spectral sensitivities, both in the retinal periphery and in the fovea, were maximal between 500 nm and 510 nm for the three photopic plateaux and for the scotopic one and fitted satisfactorily with the 1951 CIE scotopic standard. The mechanisms underlying the appearance of the up to three fast, high-intensity plateaux in the achromats' dark adaptation curves do not fulfill normal requirements completely since they are photopic as to the kinetics of their recovery and scotopic as to their spectral luminous efficiency. The data from the subjects examined indicate three types of receptors with cone kinetics during dark adaptation but containing rhodopsin. The theoretical significance of the findings is discussed, especially why rhodopsin seems to regenerate faster in cones than in rods or in the test tube. Other cases were found, one only illustrated, with only one fast high-intensity plateau similar to those described in the literature.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: 1,3,5-Trioxane (1) and 1,3-dioxep-5-ene (2) were copolymerized with BF3OEt2 at 65°C. The products, after base hydrolysis, were characterized by 13C and 1H NMR and were found to assume the chemical structure 4 of a copolymer containing oxymethylene and oxy-2-butenylene units with 4-hydroxy-2-butenyl and methoxy end groups, with the ratio of hydroxy-2-butenylene to methoxy end groups varying with experimental conditions. The copolymer demonstrates crystallinity and thermal stability comparable to poly(trioxane-co-ethylene oxide)s. Copolymer melting point was observed to decrease with increasing comonomer incorporation. The upper limit for incorporation of the comonomer 2 was found to be ca. 4 mol per cent. Viscosity and end group analysis (by 1H NMR) indicate molecular weights in the range of 104 to 105. The comonomeric unit demonstrates the ability to act as both a stopper against unzipping and as a trap for certain degrading agents.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 2 (1951), S. 365-367 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Phase boundary-lines, especially in their impotance for corrosionTwo phases have a common cleavageplane, whilst three phases touch one another along a boundary line only. Corroesponding to an adsorption in the first case in an adlineation in the second case. Both processes diminish the free energy and herewith the activity of the boundary, so inhibiting the possibilities of corrosion.Local elements, glow cathodes and catalysts consisting of several components are typical systems acting at microscopic boundary-lines. Cavitation is the inverse phenomenon.Macroscopic boundary-lines in partially filled containers, formed by wall, liquor and gaseous phase, are about this especially active, as being mixed with a four-phases-point-system, that results from the heterogeneity of the container wall. Gravity potentials, and electrokinetic potentials have their maximum value in the boundary-lines too.
    Notes: Zwei Phasen haben eine gemeinsame Grenzfläche, während drei Phasen sich nur entlang einer Grenzlinie berühren. Der Adsorption im ersten Falle entspricht eine Adlineation im zweiten Falle. Beide Vorgänge setzen die freie Energie und damit die Aktivität der Grenze herab, hemmen also Korrosionsmöglichkeiten.Lokalelemente, Glühkathoden und Mehrstoff-Katalysatoren sind typische Systeme, die an mikroskopischen Grenzlinien zur Wirkung kommen. Kavitation bildet die inverse Erscheinung hierzu.Makroskopische Grenzlinien an teilgefüllten Behältern, die durch Wandung, flüssigem Inhalt und gasförmiger Phasegebildet werden, sind darüber hinaus besonders aktiv, da sie von einem Vierphasen-Punktsystem durchsetzt sind, das infolge er heterogenität der Behälterwand resultiert.Gravitationspotentiale und elektrokinetische Potentiale haben ebenfalls in den begrenzenden Linien ihren maximalen Wert.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 5 (1954), S. 359-359 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 15 (1964), S. 700-701 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 53 (1994), S. 527-541 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Impact modification was studied for a variety of engineering thermoplastics to determine if notched Izod data obtained at various temperatures and modifier concentrations could be correlated with particle size or surface-to-surface interparticle distance of the modifier. Elastomers evaluated were characteristic of those used in commercial blend systems for those polymers, and both functionalized and nonfunctionalized materials were studied. For the single matrix polymer/elastomer-modified blend systems studied [poly(phenylene sulfide) (PPS), polyoxymethylene (POM), poly(butylene terephthalate) (PBT)], elastomer interparticle distance provides a better correlation to brittle-tough transition temperature than does particle size, as predicted by the Wu model. In POM, the dispersion morphology of the samples used was not adequate to achieve the critical interparticle distance required for supertoughening at room temperature. In this study, the critical interparticle distance has been shown to depend on the degree of crystallinity (PPS) and the modulus of the impact modifier relative to the matrix (PBT). Actual adhesion of the polymer to the matrix (variation of functionality levels) was not found to have a strong influence (PBT). In POM, the increase in impact at the brittle-tough transition was dependent on the molecular weight of the base resin. This is examined with respect to the ratio of the molecular weight (Mn) to the entanglement molecular weight (Me), which determines the critical molecular weight necessary to achieve useful physical properties. In polyester (PET)/polycarbonate (PC)/elastomer blends, the molecular weight of the primary matrix resin (PET) determined impact properties within the molecular weight range of the resin studied. This was again related to the Mn/Me ratio for PET and PC. © 1994 John Wiley & Sons, Inc.
    Additional Material: 24 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1042-7147
    Keywords: Silk ; Mechanical ; Spider ; Silkworm ; Thermal ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Dragline silk from the spider, Nephila clavipes, was characterized by thermal analysis (TGA, DSC, DMA), computational modeling, scanning electron microscopy and by quasi-static as well as high rates of strain. Thermal stability to about 230°C was observed by TGA, two transitions by DMA, -75°C, representative of localized motion in the amorphous domain, and a main chain motion associated with partial melt at 210°C. Tensile tests indicated average initial modulus, ultimate tensile strength and ultimate tensile strain of 22 GPa, 1.1 GPa and 9%, respectively. The corresponding properties of the best fibers tested were 60 GPa, 2.9 GPa and 11%, respectively. High strain rates (〉50,000%/sec) indicated similar mechanical properties to the average values indicated above. Microscopy showed compressive and tensile strains to failure of 34%. Computational modeling yielded a crystal modulus of 200 GPa.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 3 (1992), S. 323-329 
    ISSN: 1042-7147
    Keywords: Polyanhydrides ; Pulmonary neoplasms ; Mice ; Chemotherapy ; Cisplatin ; BCNU ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Investigations were undertaken to determine whether anti-cancer drugs introduced locally into the lung using bioerodible polyanhydride microspheres as carriers would demonstrate both efficacy and reduced toxicity.BCNU (carmustine) and CDDP (cisplatin), loaded in polyanhydride microspheres, were administered to mice bearing either of two tumors selected for their affinity for the lung: the B16F10 melanoma and the recently established GL26F4 glioma. Following intravenous inoculation of these tumor cells, the number of metastatic foci formed in the lung follows a predictable time course and can readily be determined. Comparisons were made between the efficacy of microspheres introduced into the lung by intratracheal intubation (IT) and of those administered by intraperitoneal injection (IP). Administration of microspheres loaded either with BCNU or cisplatin reduced the detectable metastatic foci by 25-90% depending on the tumor load, both when administered IP and IT.Toxicity was assessed by flow cytometric analysis of bone marrow cellularity as well as by determination of mortality rates. Intratracheal administration of either cisplatin or BCNU reduced the deleterious systemic effects observed when the drug was administered by IP injection. This was seen at high drug levels, where significant mortality occurred only in animals given drug injections IP; and at lower levels where IP injection led to a reduction of bone marrow blast cells, while IT administration caused no detectable effect on marrow cellularity.Since local delivery of BCNU or cisplatin through bioerodible polyanhydride microspheres induces significantly less systemic damage while demonstrating efficacy equal to or exceeding that of IP injection, this mode of drug delivery warrants further and more detailed exploration. Moreover, the method may be applicable to the treatment of other chronic pulmonary pathologies.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 45 (1992), S. 407-415 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Organosolv lignin was fractionated on a Sephadex G 75 column with 0.1M aqueous NaOH resulting in 14 fractions. These fractions were acetylated and a high-molecular-weight fraction (F3) was investigated by means of combined static and dynamic light scattering (LS) in solvents acetone, tetrahydrofuran (THF), and trifluoroethanol (TFE). The measurements were found to be reproducible, and recycling of lignin by freeze drying caused slight but unessential changes in solution properties. Depending on the solvent used, weight average molecular weights Mw between two and ten million were found. By contrast, Mn of the fractions, measured by vapor pressure osmometry (VPO), was in the range of a few thousands only. Analysis of the angular dependence in static LS by means of a Casassa-Holtzer plot and the fractal dimensions showed the presence of chain stiffness, most distinct in TFE. Also, the dynamic light scattering results in TFE are typical for semiflexible chains, while in THF, and to some extent in acetone, the dynamic measurements including viscosity suggest the presence of spherical structures. These findings are being explained by large lignin clusters that consist of stiff subunits.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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