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Digitale Medien

Evolution of the Hemaggllutinin Gene of Influenza B Virus was Driven by Both Positive and Negative Selection Pressures (1997)

Weber, J M ; Prud'homme, I ; Zou, S

Springer

Virus genes 14 (1997), S. 181-185

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Details

ISSN: 1572-994X

Schlagwort(e): influenza B virus ; hemagglutinin ; evolution ; antigenic drift

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Nucleotide sequences of the hemagglutinin (HA) gene of twelve influenza B strains and their deduced amino acid sequences were extracted from the GenBank and compared to those of early isolates. Separate analyses of nonsynonymous and synonymous substitutions for the HA1 and HA2 regions individually indicate that the percentage of nonsynonymous substitutions in the HA1 ranges from 44.4–56.0% but in the HA2 from 0.0–6.5%. The results suggest that positive selection as well as negative selection played a role in the evolution of the influenza B HA gene with the former acting on the HA1 and the latter on the HA2.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1007927725332

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