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  • Articles: DFG German National Licenses  (2)
  • Electronic Resource  (2)
  • 2005-2009
  • 1995-1999  (2)
  • 1985-1989
  • 1997  (2)
Source
  • Articles: DFG German National Licenses  (2)
Material
  • Electronic Resource  (2)
Years
  • 2005-2009
  • 1995-1999  (2)
  • 1985-1989
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  • 1
    Electronic Resource
    Electronic Resource
    FEASIBILITY OF CONDUCTING CARDIOVASCULAR OUTCOME RESEARCH IN AUSTRALIAN GENERAL PRACTICE: RESULTS FROM THE ANBP2 PILOT STUDY (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 24 (1997), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices.2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03051870:CEP370:ges" location="ges.gif"/〉 160 mmHg systolic or 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03051870:CEP370:ges" location="ges.gif"/〉 90 mmHg diastolic if systolic BP was 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03051870:CEP370:ges" location="ges.gif"/〉 140 mmHg.3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population).4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1997.tb01204.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating (1997)
    Springer
    Diabetologia 40 (1997), S. 299-301 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus ; autonomic neuropathy ; diabetic neuropathy ; diabetic nephropathy ; gustatory sweating.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The treatment of gustatory sweating in diabetes mellitus is usually with oral anti-cholinergic drugs, but these frequently lead to unacceptable side effects. Glycopyrrolate is an anti-muscarinic agent that can be applied topically and is efficacious in gustatory sweating occurring in other conditions. In a double-blind placebo-controlled crossover study, we assessed the value of glycopyrrolate in 13 diabetic patients with gustatory sweating. Sweating was measured by a sweat challenge, and diaries recorded by the patients throughout the 2 weeks of each treatment period. Compared to placebo, glycopyrrolate reduced the sweat response to a challenge by 82 % (p 〈 0.01). The frequency of episodes of gustatory sweating during the treatment period was also reduced by 51 % (p 〈 0.01), with a nearly 100 % reduction in the frequency of episodes of severe sweating (p 〈 0.01). In conclusion, topically applied glycopyrrolate is a very effective treatment in reducing both the severity and frequency of diabetic gustatory sweating. [Diabetologia (1997) 40: 299–301]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050677
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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