ISSN:
1573-4935
Keywords:
complement
;
factor H
;
C4b-binding protein, C2, factor B
;
β2-glycoprotein
;
interleukin-2 receptor
;
sequence homology
;
cDNA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Factor H, a control protein of the human complement system, is closely related in functional activity to two other complement control proteins, C4b-binding protein (C4bp) and complement receptor type 1 (CR1). C4bp is known to have an unusual primary structure consisting of eight homologous units each about 60 amino acids long. Such units also occur in the N-terminal regions of the complement proteins C2 and factor B, and in the non-complement serum glycoprotein β2I. Amino acid sequencing, and sequencing of a factor H cDNA clone, show that factor H also contains internal repeating units, and is homologous to the proteins listed above.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01145180
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