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  • Articles: DFG German National Licenses  (13)
  • Electronic Resource  (13)
  • 1985-1989  (13)
  • General Chemistry  (7)
  • Genetics  (4)
  • Cardiac output  (2)
Source
  • Articles: DFG German National Licenses  (13)
Material
  • Electronic Resource  (13)
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 15 (1987), S. 603-617 
    ISSN: 1573-9686
    Keywords: Blood temperature ; Thermodilution ; Heat transport ; Cardiac output
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Pulmonary artery blood temperature manifests large variations which obscure the measurement of cardiac parameters by thermodilution techniques. We have created three mathematical models of heat flow through the heart in order to better understand the origins of the temperature fluctuations in the pulmonary artery. These lumped parameter models are based on a serial connection of two mixing chambers, which correspond to the atrium and ventricle of the heart. We have used the models to predict temperature fluctuations in the outlet, based on measurements of inlet flow, inlet temperature, and the timing of the cardiac cycle, of a mechanical right artificial heart in a mock circulatory loop. The most complex model accurately predicts the outflow temperature from the input variables and provides a quantitative description of heat transport across the heart under many operating conditions. The simplified models illustrate the conditions under which is possible to predict the outflow temperature from the inflow temperatures alone.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 16 (1988), S. 265-278 
    ISSN: 1573-9686
    Keywords: Thermodilution ; Pulmonary artery blood temperature ; Signal processing ; Cardiac output
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Thermodilution measurements of clinically important cardiac parameters, such as cardiac output and stroke volume, are subject to many sources of error. The temperature fluctuations (thermal noise) normally found in the pulmonary artery constitute one of these sources of errors. To improve the signal-to-noise ratio of thermodilution flow measurements rather than increase the signal level, we investigated four signal processing strategies designed to reduce the thermal noise power. We applied the noise reduction strategies to thermal noise data, containing simulated thermodilution curves, obtained in a mock circulatory loop. We compared the accuracy and reproducibility of the curve area estimates produced by the algorithms to the area estimates obtained by numerical integration of the thermal signal. Our results show that a bandpass (BP) integration technique combined with a noise canceler can improve thermodilution curve area estimate reproducibility and accuracy. The BP integration technique improved the reproducibility of cardiac output measurements by roughly 16 dB and is directly applicable to most thermodilution hardware currently in use. The more accurate noise cancelers, combined with the BP integration technique, provided correspondingly improved signal-to-noise ratios, with the improvement ranging up to 50 dB.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 8 (1987), S. 125-133 
    ISSN: 0192-253X
    Keywords: retrovirus ; embryonal carcinoma ; embryonic gene ; DNA methylation ; gene expression ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Northern blot analysis and in vitro nuclear transcription assays were performed in order to clarify conflicting reports on the expression of intracisternal A particle (IAP) genes in embryonal carcinoma (EC) cell lines. Results demonstrate that post-transcriptional mechanisms control the final steady-state levels of IAP RNA in EC cells. IAP genes were further found to be undermethylated in IAP-expressing EC cell lines.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 337-350 
    ISSN: 0192-253X
    Keywords: Dictyostelium ; cAMP ; receptor ; gene regulation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have examined the expression of a cAMP pulse-repressed and two cAMP pulse-induced genes in response to cAMP and caffeine under a number of different physiological conditions, and in several classes of developmental mutants altered in cAMP-mediated signal transduction pathways. The data presented help characterize the mutants with regard to early gene expression. Analysis of the data indicates that full induction of the pulse-induced or repression of the pulse-repressed genes requires cycles of activation and adaptation of the cAMP receptor but does not require a rise in intracellular cAMP. Comparison of the results obtained between different mutant classes suggests that repression and activation of the two classes of genes can be uncoupled, implying that different intracellular mechanisms control these processes. In addition, we examined the effects of caffeine and show that it can induce pulse-induced mRNA accumulation in the absence of cAMP.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 101 (1989), S. 1235-1243 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bis vor kurzem war die Produktion von Galliumarsenid, Indiumphosphid und verwandten Halbleitern eine Domäne der Materialwissenschaftler und Elektroingenieure. Durch geschickten Einsatz der klassischen Chemie, veranschaulicht an der thermischen Reaktion von Me3Ga und AsH3, ist es möglich, Halbleiter in kommerziellem Maßstab herzustellen. Es gibt jedoch einige Nachteile dieser Methoden, so die Umwelt- und Gesundheitsrisiken bei der Handhabung pyrophorer und giftiger Materialien, Probleme bei der Kontrolle der Stöchiometrie und unerwünschte Nebenreaktionen. Kann der anorganisch oder metallorganisch orientierte, präparativ arbeitende Chemiker auf diesem wichtigen Gebiet durch Konzeption und Entwicklung neuer Reagentien für die Produktion von Halbleitern eine nützliche Rolle spielen? Wir glauben, die Antwort lautet ja, und in dem vorliegenden Beitrag diskutieren wir einen neuen Weg zur Herstellung von dünnen GaAs- und InP-Filmen, basierend auf III/V-Komplexe als einziger Quelle. Diese Komplexe weisen starke Bindungen zwischen den Elementen der III. und V. Hauptgruppe des Periodensystems auf, und sie tragen Substituenten, die leicht thermisch eliminiert werden können. Die III/V-Komplexe sind gegenüber Luft und Feuchtigkeit stabiler und erheblich weniger toxisch als Addukte oder Mischungen aus III- und V-Verbindungen.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 100 (1988), S. 1396-1397 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 435-454 
    ISSN: 0192-253X
    Keywords: cis-acting sequences ; trans-acting factors ; gene regulation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Expression of the Dictyostelium discoideum pst-cath (CP2) gene is transcriptionally regulated during multicellular development, and the gene is inducible in competent single cells following administration of exogenous cAMP. The 5′ flanking region of pst-cath (CP2) that extends from -313 to the Cap site (+-1) has previously been shown to contain sufficient cis,-acting regulatory elements for proper developmental and cAMP-inducible expression of a foreign gene [Datta and Firtel, 1987, Mol Cell Biol 7:149-159]. The -283 to -201 region includes two exceptional “G-boxes” centered at -233 and -217 respectively, and this ∼ 80 bp region is essential for basal as well as regulated expression of the pst-cath (CP2) gene. Here we summarize results obtained from a detailed analysis of a series of linker-scanner mutants and mutants that carry small internal deletions within the essential 80-bp region. Insertion of a synthetic oligonucleotide that includes the downstream G-box is demonstrated to rescue a low level of cAMP-inducible expression following insertion into cassette mutants. The effect of introducing a change in the relative spacing between regulatory elements has also been investigated.We have analyzed nuclear extracts for the presence of DNA-binding proteins that interact specifically with the pst-cath (CP2) regulatory region and identified two such putative trans-acting factors: (1) the AT-factor that is observed within a few hours following the onset of starvation and that binds tightly to stretches of alternating adenine-thymine residues (poly(dA-dT)); and (2) the AG-factor that is present in nuclear extracts of aggregated cells. Competition studies have demonstrated significant differences in the affinity that characterizes the binding of the two factors to G-box-containing sequences. The binding specificities of these DNA-binding proteins have been analyzed using gel mobility-shift and DNaseI footprinting assays.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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