ISSN:
1434-4475
Keywords:
Contraction of ring A
;
Photo-Wolff-rearrangement
;
Pleuromutilin
;
Tricyclic diterpene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Derivatives of the antibiotic pleuromutilin are rapidly metabolised in animals. This phenomenon is responsible for the lack of biological activity of these compoundsin vivo although their activitiesin vitro are extremely high (MHK=0,005–0.1 μg/ml). In order to reduce the rate of metabolism a compound with slightly modified conformation (15) in the appropriate region of the molecule (C-1, C-2)3a was chosen for biological tests. The synthesis of this compound is described in detail.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00900009
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