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  • Articles: DFG German National Licenses  (8)
  • Electronic Resource  (8)
  • 1980-1984  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Ovine urinary metabolites of hymenoxon, a toxic sesquiterpene lactone isolated from Hymenoxys odorata DC (1983)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 31 (1983), S. 1208-1210 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00120a016
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tissue distribution and disposition of hymenoxone (1980)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 28 (1980), S. 1269-1273 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60232a032
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dimethylphosphorothioates (1982)
    Springer
    Archives of toxicology 49 (1982), S. 293-301 
    Details
    ISSN: 1432-0738
    Keywords: Dimethylphosphorothioates ; Trimethylphosphorothioates ; Malathion ; Thin layer chromatography ; Carboxylesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five dimethylphosphorothioates were tested for their toxicity to rats, potentiation of malathion toxicity in rats, inhibition of carboxylesterase in vitro, and reaction with malathion in vitro. The compounds were: potassium salts of (CH3S)2P(O)O−(I), (CH3O)(CH3S)P(O)S−(II), (CH3O)2P(O)S−(III), (CH3O)2P(S)S−(IV), and (CH3O)(CH3S)P(O)O−(V). The dimethylphosphorothioates are not toxic to rats (up to 1 g/kg, orally), they do not potentiate malathion toxicity in rats, and do not inhibit carboxylesterase activity in vitro (up to 1 mM concentrations). However, when the S-acid diesters (II, III, IV) are incubated with malathion for several days at room temperature or for several hours at 50° C they become methylated forming the trimethylphosphorothioates OSS-trimethyl phosphorodithioate, OOS-trimethyl phosphorothioate and OOS-trimethyl phosphorodithioate respectively, which potentiate malathion toxicity. Furthermore, these same acid diesters increase the rate of isomerization of malathion into OS-dimethyl-S-(1,2-dicarbethoxyethyl) phosphorodithioate (isomalathion) particularly, diester IV. The formation of the trimethylphosphorothioates and isomalathion from the interaction of the S-acid diesters with malathion was determined by thin layer chromatography (TLC), gas chromatography and mass spectrometry and could be detected by in vitro inhibition of carboxylesterase. TLC methods can detect 1 mg of the trimethylphosphorothioates and isomalathion per gram malathion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347877
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  • 4
    Electronic Resource
    Electronic Resource
    Hydrolysis of oleylanilide in the rat (1983)
    Springer
    Archives of toxicology 54 (1983), S. 157-162 
    Details
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fate of oleylanilide, administered as a single intragastric dose in rape oil, has been studied in Porton Wistar rats. Following a dose of oleyl[U-14C]anilide approximately 60% of the label was recovered in the faeces over a 3 day period, and identified principally as unchanged anilide. Most of the remainder of the dose was recovered in urine as hydrophilic metabolites,p-hydroxyacetanilide, which is a major metabolite of aniline in the rat was identified in the hydrolysed samples of urine from anilide treated rats. Following administration of [9,10(n)-3H]oleyl[U-14C]-anilide to rats which had been fitted with a cannula in the thoracic lymph duct the [3H] label which was absorbed was recovered principally in triglycerides showing that extensive hydrolysis of the anilide occurs prior to or during uptake from the gut. Oleylanilide was identified in lymph by gas chromatography but amounted to less than 6% of the dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261384
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Resource estimation from historical data: Mercury, a test case (1980)
    Springer
    Mathematical geology 12 (1980), S. 489-522 
    Details
    ISSN: 1573-8868
    Keywords: mercury ; resource estimation ; production data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract A simple technique based on historical records of tonnage and grade of ore produced provides a means for calculating how much of a mineral product will be available in the future at various average grades. Estimates made on this basis are independent of geologic considerations or changing economic and political factors, although they are based on mining history, which was largely determined by these factors. The relatively minor element, mercury, was used for the test case reported here, but the method has been found applicable to forecasts of resources for other mineral products. Mercury resources available in ore in which the average grade is as low as 0.1% are estimated to be 53 ×10 6 kg (1.5 ×10 6 flasks) for the United States and 1551 ×10 6 kg (45 ×10 6 flasks) for the world; this amount is more than adequate to meet predicted demand to the year 2000. The expectable price of mercury in 1978 dollars at this 0.1% grade is projected to be $58.75 per kg ($2,025 per flask), but at a 10% annual inflation rate, it would be more than $12,000 per flask. To satisfy just the projected U.S. demand for mercury by 2000, the price is calculated to be $48.96 per kg ($1,688 per flask) in 1978 dollars at an average annual grade of 0.12%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01028882
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Determination of fatty acid anilides in contaminated cooking oils using high resolution capillary gas chromatography (1983)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 6 (1983), S. 452-453 
    Details
    ISSN: 0935-6304
    Keywords: Capillary gas chromatography ; Fatty acid anilides ; Contaminated cooking oils ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240060814
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  • 7
    Electronic Resource
    Electronic Resource
    Approach to the quantitation of alkylated amino acids in haemoglobin by gas chromatography mass spectrometryA preliminary communication of this work was presented at the 8th International Mass Spectrometry Conference, Oslo (1979). Abbreviations: PFP = pentafluoropropionyl; HFB = heptafluorobutyryl. (1980)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1980), S. 41-46 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: As a result of the increasing concern over the environmental exposure of humans to carcinogenic alkylating agents, assay methods are being developed in order to quantitate the extent of in vivo alkylating reactions. Such methods will be of value also in connection with the use of alkylating agents as anti-cancer drugs. The reactions carried out by these compounds include the alkylation of cysteine in proteins, and a procedure has now been developed for the estimation of S-methylcysteine in haemoglobin following exposure of rats to the carcinogen methyl methanesulphonate. Haemoglobin is particularly appropriate for the analysis of alkylating agent reactions as this protein is readily available from blood and has a long in vivo half-life. The analytical method involved isolation of globin from blood, hydrolysis in 6 M hydrochloric acid, partial purification of S-methylcysteine by chromatography on Dowex 50 ion exchange resin, and subsequent analysis by gas chromatography mass spectrometry. The amino acid mixtures were derivatized by n-butyl ester formation and N-heptafluorobutyrylation, and were chromatographed on a capillary column coated with OV-101 or Chirasil-Val using a solid injection system. For the mass spectrometric determination [2H3]-S-methylcysteine was employed as an internal standard. Monitoring of the [MH]+ ion of derivatized S-methylcysteine in chemical ionization (isobutane) allowed the detection of 10 pg of the compound with a signal-to-noise ratio of 20:1.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200070109
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  • 8
    Electronic Resource
    Electronic Resource
    Determination of hydroxypropylhistidine in haemoglobin as a measure of exposure to propylene oxide using high resolution gas chromatography mass spectrometryA preliminary communication of this work was presented at the Joint Meeting of the Royal Society, of Chemistry and the British Mass Spectrometry Society, Dundee, UK, 1981. (1982)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1982), S. 69-71 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The alkylating agent propylene oxide is a potential carcinogen. Exposure to this compound leads to the formation of N-3′-(2-hydroxypropyl)histidine in protein. A sensitive and specific method has been developed for the determination of this alkylated amino acid in rat and human haemoglobin using high resolution gas chromatography with selected ion monitoring. Globin isolated from blood was hydrolysed with 6 M HCI and the protein hydrolysate chromatographed on a Dowex 50W H+ column. The amino acids in the partially purified extract were analysed as N-heptafluorobutyryl methyl esters using an SE-52 fused silica capillary column. Quantification was made by monitoring the ion m/z 560 [M — COOCH3]+ derived from the derivatized hydroxypropylhistidine in the sample and the corresponding ion at m/z 565 from the pentadeutero analogue of the alkylated amino acid added initially to the globin as an internal standard. The method has been used to quantify hydroxypropylhistidine down to levels of 2 μg gm-1 haemoglobin and has been applied to studies in rats exposed to propylene oxide.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200090205
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