ISSN:
1432-1912
Keywords:
Kainic acid
;
Adenylate cyclase
;
cGMP
;
Striatum
;
Cerebellum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The bilateral intrastriatal injection of kainic acid (2 μg/caudate) caused a marked decrease in the activity of striatal dopamine-sensitive adenylate cyclase. This probable loss of target cells for dopamine was associated with a parallel decrease of the cGMP level in the cerebellar cortex, which was maximal (80% loss) by 24 h and prevented apomorphine from raising cerebellar cGMP levels. On the contrary harmaline and isoniazid both increased the levels of cerebellar cGMP in kainic-lesioned rats to the same extent as in control rats. The results indicate that dopamine mechanisms in the striatum are involved in the regulation of cerebellar cortex cGMP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501370
Permalink
