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  • Articles: DFG German National Licenses  (2)
  • Electronic Resource  (2)
  • Antibiotic treatment  (1)
  • Children  (1)
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  • Articles: DFG German National Licenses  (2)
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  • Electronic Resource  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of elective antibiotic therapy on resting energy expenditure and inflammation in cystic fibrosis (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 711-716 
    Details
    ISSN: 1432-1076
    Keywords: Key words Cystic fibrosis ; Resting energy expenditure ; Antibiotic treatment ; TNF-α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cystic fibrosis (CF) patients often present with malnutrition which may partly be due to increased resting energy expenditure (REE) secondary to inflammation. Both REE and tumour necrosis factor-alpha (TNF-α), as other markers of inflammation, are elevated during respiratory exacerbations and decrease after antibiotic treatment. However, the effect of antibiotic therapy on REE and inflammation in patients without respiratory exacerbation is not known. The aim of our study was to determine the effect of such an elective antibiotic therapy on REE, TNF-α, and other serum markers of inflammation. Twelve CF patients 5F/7M, age 15.9 ± 6.1 years, weight for height ratio 89 ± 8% without clinically obvious exacerbation and treated by intravenous antibiotics were studied. Both before (D0) and after (D14) treatment, pulmonary function tests were performed. REE was measured by indirect calorimetry and blood taken to measure inflammation parameters. Body weight increased by 1.1 kg from D0 to D14 (P 〈 0.001), composed of 0.3 kg fat mass and 0.8 kg fat-free mass (FFM). The forced expiratory volume at 1 s increased from 43 ± 15% of predicted at D0 to 51 ± 15% of predicted at D14 (P 〈 0.01). Mean REE was 41.1 ± 7.6 kcal/kg FFM per day at D0 and did not change significantly at D14 (40.6 ± 8.5 kcal/kg FFM per day). Serum markers of inflammation decreased from D0 to D14: C-reactive protein 17 ± 17 mg/l to 4 ± 7 mg/l (P 〈 0.05), elastase 62 ± 29 μg/l to 45 ± 18 μg/l (P 〈 0.02), orosomucoid acid 1.25 ± 0.11 g/l to 0.80 ± 0.15 g/l (P 〈 0.001), and TNF-α 37 ± 14 pg/ml to 29 ± 6 pg/ml (P = 0.05). Individual values showed a correlation between changes in REE and in TNF-α (P 〈 0.02). Conclusion The contribution of inflammation to energy expenditure is possible but appears to be minimal in cystic fibrosis patients treated by antibiotics on a regular basis in the absence of clinically obvious exacerbation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051185
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Meal-induced thermogenesis in obese children with or without familial history of obesity (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 128-131 
    Details
    ISSN: 1432-1076
    Keywords: Resting metabolic rate ; Meal induced thermogenesis ; Obesity ; Children ; Familial dependence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Resting metabolic rate (RMR) and the thermic effect of a meal (TEM) were measured in a group of 26 prepubertal children divided into three groups: (1) children with both parents obese (n=8, group OB2); (2) children with no obese parents and without familial history of obesity (n=8, OB0); and (3) normal body weight children (n=10, C). Average RMR was similar in OB2 and OB0 children (4785±274 kJ/day vs 5091±543 kJ/day), but higher (P〈0.05) than in controls (4519±322 kJ/day). Adjusted for fat-free mass (FFM) mean RMRs were comparable in the three groups of children (4891±451 kJ/day vs 5031±451 kJ/day vs 4686±451 kJ/day in OB2, OB0, and C, respectively). The thermic response to the mixed meal was similar in OB2, OB0 and C groups. The TEM calculated as the percentage of RMR was lower (P〈0.05) in obese than in control children: 10.2%±3.1% vs 10.9%±4.3% vs 14.0%±4.3% in OB2, OB0, and C, respectively. The similar RMR as absolute value as well as adjusted for FFM, and the comparable thermic effect of food in the obese children with or without familial history of obesity, failed to support the view that family history of obesity can greatly influence the RMR and the TEM of the obese child with obese parents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072489
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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