ISSN:
1434-4475
Keywords:
Pleuromutilin
;
Ketol-isomerization
;
11,2-Hydride-shift
;
1,2-Carbonyl-transposition
;
Photoaddition to enones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract 2-Hydroxy-19,20-dihydropleuromutilin (10) undergoes a stereospecific ketolisomerisation when treated with base under phase/transfer conditions (11, 12). The subsequent reductive elimination of the 3-acetoxygroup afforded mutilin with a 1,2-transposed ketofunction (13).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00811250
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