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Ribonuclease H levels in Herpes simplex virus-infected cells (1980)

Müller, W. E. G. ; Falke, D. ; Zahn, R. K. ; [et al.]

Springer

Archives of virology 64 (1980), S. 269-275

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ISSN: 1432-8798

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Two forms of ribonuclease H (RNase H) have been identified both in uninfected and Herpes simplex virus (HSV-)infected BHK cells. Identical RNase H species were detected in control- as well as in infected cells. RNase H I and II have not been found to be associated both with host cell DNA polymerase α and β and HSV-induced DNA polymerase. Infection of BHK cells with HSV type 1 does not lead to a pronounced alteration of RNase H II activity but to an increases (3-fold) of the extractable RNase H I activity. RNase H I activity increases to a maximum between 8–10 hours p.i.; the bulk of HSV-DNA synthesis occurs between 6–8 hours p.i. From these experiments we draw the preliminary conclusion that RNase H I is involved in the degradation of the RNA primer which is covalently linked to newly synthesized HSV-DNA strands.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01322706

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