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  • 1
    Electronic Resource
    Electronic Resource
    Nucleotide sequence of the mannitol (mtl) operon in Escherichia coli (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 2 (1988), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The nucleotide sequence of the known portions of the mannitol operon in Escherichia coli (mtlOPAD) has been determined. Both the operator-promoter region and the intercistronic region between the mtlA and mtID genes (encoding the mannitol-specific Enzyme II of the phosphotransferase system and mannitol–1- phosphate dehydrogenase, respectively) show parallels with corresponding regions of the glucitol (gut) operon, but neither the mtlA nor the mtlD gene products show obvious homology with the corresponding gene products of the glucitol operon. Five potential cyclic AMP receptor protein binding sites were identified in the mtlOP region, all showing near identity with the consensus sequence. Four regions of dyad symmetry (four to seven bases in length), serving as potential repressor binding sites, overlap with the potential cyclic AMP receptor protein binding sites. Repetitive extragenic pallndromic (REP) sequences, forming stem-loop structures in the intercistronic region between mtlA and mtlD and following the mtlD gene were identified. Probable terminator sequences were not found in any of these three regulatory regions. Mannitol–1-phosphate dehydrogenase exhibits two overlapping, potential NAD+ binding sites near the W-terminus of the protein. Computer techniques were used to analyse the mtlD gene and its product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1988.tb00045.x
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  • 2
    Electronic Resource
    Electronic Resource
    An adoptive immunotherapy of patients with medulloblastoma by lymphokine-activated killer cells (LAK) (1988)
    Springer
    Acta neurochirurgica 94 (1988), S. 47-52 
    Details
    ISSN: 0942-0940
    Keywords: Brain neoplasms ; medulloblastoma ; lymphokine-activated killer (LAK) cells ; adoptive immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An adoptive immunotherapy of 6 patients with medulloblastoma by lymphokine-activated killer (LAK) cells is described. They were from 2 to 9 years in age and had cerebrospinal fluid (CSF) dissemination of the tumours. All patients underwent the whole-neuraxis irradiation and chemotherapy. After the usual treatments, they were submitted to an adoptive transfer of one-haplotype identical LAK cells. The LAK cells were induced from peripheral blood lymphocytes (PBL) of their relatives with human recombinant interleukin-2 (rIL-2). 3–15×109 LAK cells were transferred intrathecally in 2–3 months. In 3 of 6 patients, neurological signs were improved and malignant cells had never been detected on CSF cytology after the adoptive immunotherapy. One among these 3 patients showed complete response in 20 months. Thus, this is an attractive approach for the treatment of medulloblastoma with CSF dissemination of the tumour which current therapeutic intervention can not cure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406615
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  • 3
    Electronic Resource
    Electronic Resource
    Systemic amyloid deposition in old age and dementia of Alzheimer type: the relationship of brain amyloid to other amyloid (1988)
    Springer
    Acta neuropathologica 77 (1988), S. 136-141 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid deposition ; Amyloid protein ; Ageing ; Dementia of Alzheimer type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated amyloid deposition in the brain and other organs in 105 consecutive autopsy cases, aged 59 to 101 years. They consisted of two groups; 15 patients with dementia of Alzheimer type (DAT) and 90 patients without DAT. Amyloid deposition was found in 93% of all cases. The incidence of amyloid deposition increased with age. The number of organs affected with amyloid deposition in each case also increased with age. The incidence of amyloid deposition in each organ was as follows; 88% in pituitary gland, 66% in brain [amyloid of senile plaque (SP) (61%) and/or cerebral amyloid angiopathy (CAA) (56%)], 33% in pancreas, 3% in heart, and less in others. In immunohistochemical studies using the antisera to the various kinds of amyloid or related proteins, amyloid β protein was demonstrated in brain amyloids including SP and CAA, but not in others. Cardiac amyloid was positive for prealbumin. Pituitary amyloid and CAA were positive for amyloid P-component. The incidence of brain amyloids in DAT were significantly higher than that in non-DAT. There was no significant difference in the incidence of pituitary and pancreatic amyloid between DAT and non-DAT. In the non-DAT patients, there were significant positive correlations in amyloid deposition between the brain and pituitary gland and between the brain and pancreas. Acceleration of amyloid deposition would be a process confined to the brain in the patients with DAT. The pathogenesis of the accelerated deposition of brain amyloids is discussed from the point of view of amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687423
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of contact photosensitivity to TCSA using photohapten-modified syngeneic spleen cells (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 207-213 
    Details
    ISSN: 1432-069X
    Keywords: Contact photosensitivity ; Photohaptenmodified cells ; Tetrachlorosalicylanilide ; Delayed-type hypersensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the induction and transfer of contact photosensitivity (CPS) to the photohapten 3,3′,4′,5-tetrachlorosalicylanilide (TCSA) using photo-TCSA-coupled syngeneic cells in mice. Photo TCSA-modified spleen cells (photo TCSA-SC) with efficient immunogenicity were prepared with ultraviolet A (UVA) irradiation of spleen cells suspended in TCSA solution. Subcutaneous inoculation of photoTCSA-SC into syngeneic mice induced a highly specific CPS response detected by ear swelling upon epicutaneous challenge with TCSA painting plus UVA irradiation. The sensitivity was determined to be a cell-mediated, delayedtype hypersensitivity reaction from the time course of the reactivity, the characteristic histology, and the successful transfer of the sensitivity into syngeneic naive recipients by immune lymph node T cells with the phenotype of L3T4+, Lyt-2-. In contrast to the conventional TCSA painting plus UVA irradiation method, this immunization procedure did not evoke an ordinary contact sensitivity reaction to TCSA. The present procedure represented a new way to induce CPS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00513959
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  • 5
    Electronic Resource
    Electronic Resource
    HTLV-I-associated meningitis (1988)
    Springer
    Journal of neurology 235 (1988), S. 129-130 
    Details
    ISSN: 1432-1459
    Keywords: Human T-cell lymphotropic virus type I ; Chronic myelopathy ; Meningitis ; Adult T-cell leukaemia/lymphomalike cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 69-year-old woman with human T-cell lymphotropic virus type I (HTLV-I) positive chronic myelopathy became comatose with acute meningitis. Most of the cells in the cerebrospinal fluid were similar to those found in adult T-cell leukaemia/lymphoma, which suggests that there is a close relationship between HTLV-I and this form of meningitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314300
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  • 6
    Electronic Resource
    Electronic Resource
    Peripheral neuropathy with predominantly motor manifestations in a patient with carcinoma of the uterus (1988)
    Springer
    Journal of neurology 235 (1988), S. 368-370 
    Details
    ISSN: 1432-1459
    Keywords: Motor-dominant neuropathy ; Carcinoma of the uterus ; Paraneoplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of a 56-year-old woman who had carcinoma of the corpus uteri and peripheral neuropathy with predominantly motor manifestations is described. The neurological abnormalities included subacute weakness of the limbs and loss of deep reflexes, which improved after the surgical removal of the uterine carcinoma. Neuropathologically, peripheral nerves mainly presented features of axonal degeneration with a mild loss of myelinated fibres. Anterior horns of the spinal cord showed central chromatolysis of the motor nerve cells and many spheroids without neuronal loss. Axonopathy of peripheral nerves was considered to be the main pathological process in this paraneoplastic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314236
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice (1988)
    Springer
    Archives of virology 99 (1988), S. 101-109 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311027
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  • 8
    Electronic Resource
    Electronic Resource
    Surface-layer oxidation of copper-implanted aluminum nitride (1988)
    Springer
    Journal of materials science 7 (1988), S. 1233-1234 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00722346
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