ISSN:
1432-2072
Keywords:
Rotational behavior
;
Striatum
;
Dopamine
;
Uptake
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The relationship between circling behavior and the dopaminergic (DA) innervation of the striatum was investigated in rats. Vmax for DA uptake in crude mitochondrial (P2) fractions was used as a measure of the density of striatal DA terminals. Females, as a group, rotated away from (i.e., contralateral to) the side containing the higher V max for DA uptake, while there was a nonsignificant trend in the opposite direction for the males. Further analysis suggested that in both sexes there are two kinds, or populations, of rats: those with their turning biases directed away from (Contra〉Ipsi rats), and those with their turning biases directed towards (Ipsi〉Contra rats) the side containing the striatum with the higher V max for DA uptake. Evidence supporting this two-population hypothesis includes: (a) For both groups of rats the slope of the best fit linear relationship between the contralateral/ipsilateral V max asymmetry and rotational behavior is equal in magnitude, though opposite in sign; (b) Mean contralateral V max is greater for the Contra〉Ipsi rats than for the Ipsi〉Contra rats, while the mean ipsilateral V max is virtually identical for the two groups; (c) The two groups of rats can be differentiated behaviorally on the basis of a measure of total lateralized activity, % turning. In addition, the K m for DA uptake for the females (1.81±0.07×10−7 M) was found to be significantly greater than for the males (1.51±0.04×10−7 M; P〈0.005).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00175184
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