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  • Articles: DFG German National Licenses  (2)
  • 2005-2009
  • 1980-1984  (2)
  • DNA content of tumour cell nuclei  (1)
  • Lymphocytes  (1)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 2005-2009
  • 1980-1984  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 317-318 
    ISSN: 1432-1440
    Keywords: Adenosine deaminase ; Lymphocytes ; Cell-mediated immunity ; Hodgkin's disease ; Adenosine deaminase ; Lymphozyten ; Zellvermittelte Immunität ; Morbus Hodgkin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Aktivität der Adenosindesaminase (EC3.5.4.4.) ADA in Blutplasma, Erythrozyten und Lymphozyten wurde bei 23 Patienten mit Morbus Hodgkin und teilweise bei 99 Referenzpersonen bestimmt. Die Enzymaktivitäten wurden mit Adenosin als Substrat und durch Analyse des Ammoniaks gemessen. Zwischen den ADA-Aktivitäten in Blutplasma, Erythrozyten und Lymphozyten wurde keine Korrelation festgestellt. Die Lymphozyten der Patienten wiesen niedrigere ADA-Aktivitäten auf als die Lymphozyten der Referenzpersonen. Die ADA-Aktivität in Plasma oder Erythrozyten ist nicht vermindert. Die herabgesetzten ADA-Aktivitäten in den Lymphozyten der Patienten können zur gestörten zellvermittelten Immunantwort bei Morbus Hodgkin in Beziehung gesetzt werden.
    Notes: Summary The activity of adenosine deaminase (ADA) (EC3.5.4.4.) was determined in the blood plasma, erythrocytes, and lymphocytes of 23 patients with Hodgkin's disease and partly also in 99 control subjects. The enzyme activities were measured using adenosine as substrate and by analysis of ammonia. No correlation was found between the ADA activities in lymphocytes, erythrocytes, and blood plasma. The lymphocytes of the patients revealed lower ADA activities (U/g protein) than the lymphocytes of control subjects. The ADA activity is not reduced in plasma or erythrocytes. The lower activities of ADA in the lymphocytes of patients may be related to the impaired cell-mediated immunity of the Hodgkin's disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 49 (1980), S. 123-132 
    ISSN: 1432-0533
    Keywords: Brain tumours ; Flow-through cytophotometry ; DNA content of tumour cell nuclei ; Ploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The flow-through cytophotometric method was used to investigate the single-cell DNA content in 60 tumours of the CNS and allied structures (9 meningiomas, 5 ependymomas, 15 astrocytomas, 11 anaplastic astrocytomas, 8 glioblastomas, 7 medulloblastomas, 2 oligodendrogliomas, 1 anaplastic oligodendroglioma, and 2 neurinomas). The cytophotometric parameters were correlated with morphological and clinical data of the tumours. The results are summarised in Tables 1–7. With regard to the DNA content of their cell nuclei, the gliomas present a behaviour similar to tumours in other organs, but in the present study the cytophotometric signs of malignancy in gliomas are not so evident as in carcinomas or sarcomas. The information obtained by flow cytophotometric methods may be helpful in diagnosing the degree of malignancy in brain tumours.
    Type of Medium: Electronic Resource
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