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Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up (2005)

Ito, M. ; Tanaka, S. ; Takata, S. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Alimentary pharmacology & therapeutics 21 (2005), S. 0

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ISSN: 1365-2036

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Background : It is controversial as to whether the development of gastric cancer is influenced by Helicobacter pylori eradication. If eradication itself influences the tumour morphology, this may affect the tumour discovery rate.Aim : To investigate the morphological changes in the gastric neoplasm after H. pylori eradication.Methods : We studied 37 patients with eradication therapy. After a 1-month follow-up, endoscopic re-evaluation was performed and the appearance was compared with first image. All lesions were resected endoscopically, and were subjected to histological assessment and to immunohistochemistry. Serum gastrin levels were determined before and after eradication.Results : Twenty-nine of 37 patients underwent successful eradication. The appearance of 11 lesions (33% of 33 lesions) became indistinct after successful eradication. All lesions were of the superficial-elevated type and the height of the lesions decreased. We detected normal columnar epithelium over the neoplasm in eight of the lesions. Higher expression of single-stranded deoxyribonucleic acid in the deep area was characteristic in tumours with an indistinct appearance. These changes did not correlate with the serum gastrin levels.Conclusions : The morphology of the gastric neoplasm change after eradication in the short-term. This may contribute to the decreased tumour discovery rate.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02360.x

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Tagging studies on the growth of the sea hare Aplysia kurodai on an intertidal rocky shore (1975)

Nishiwaki, S. ; Ueda, H. ; Makioka, T.

Springer

Marine biology 32 (1975), S. 389-395

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ISSN: 1432-1793

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract A total of 1,427 juvenile Aplysia kurodai were tagged and released during spring tides in January and February, 1973, on the rocky shore of Nabeta Bay, Japan. Recapture, weighing and release were repeated within a defined observation area during 10 spring tides from late January to early June. Recapture rates decreased with time and became significantly low after the end of the spawning season (March and April in this area). Of 1,427 individuals released, 550 (ca. 39%) were never recaptured. Only 68 individuals (ca. 5%) were recaptured 5 to 10 times during the observation period. The growth curves of these 68 individuals displayed a common growth pattern of body weight increasing almost linearly, attaining a maximum during the spawning season and then decreasing gradually. The maximum weight varied fairly widely from one individual to another. Laboratory measurements indicated a growth pattern similar to that observed in the field, and a fairly remarkable daily fluctuation in body weight was observed under laboratory conditions. The described tagging-recapture method, with slight modifications, should prove useful for future studies on the life history and ecology of A. kurodai.