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  • Articles: DFG German National Licenses  (6)
  • 2000-2004  (2)
  • 1990-1994  (4)
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  • Articles: DFG German National Licenses  (6)
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Observation of optical bistability by charge-induced self-feedback in biased AlGaAs multiple quantum well structures (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 419-421 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new type of optical bistable device is demonstrated. We report the first observation of optical bistable switching caused by charge-induced self-feedback due to field screening in GaAs/AlGaAs multiple quantum well structures, both at room temperature and at low temperature (110 K). A bias voltage supply is directly connected to the p-i-n diode with the multiple quantum well structure to attain optical bistability. Since no external series resistance is required, the device is attractive from the standpoint of a practical application. The mechanism for the self-feedback underlying the operation of the device is elaborated. The theoretical consideration about the resolvable spot size on the device operation is shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103653
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180 (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the present study we further investigate functions of the neural cell adhesion molecule (NCAM) in the mature central nervous system and its implications for animal behaviour. To this end we generated transgenic mice expressing the major NCAM isoform with the largest cytoplasmic domain, NCAM180, under control of a promoter for the small form neurofilament gene. Transgenic mice were also bred with mice deficient in endogenous NCAM (Ncam–/– mice) so that effects of NCAM180 could be analysed in the presence and absence of endogenous NCAM. While overexpression of transgenic NCAM180 was without apparent behavioural or morphological effect, its expression in Ncam–/– mice counteracted NCAM ablation-induced aggressive, anxiety-like and antidepressant-like behaviour. It furthermore prevented a hypersensitivity of Ncam–/– mice to the anxiolytic serotonin1A (5-HT1A) receptor agonist buspirone. Such recovery of emotional behaviour and behavioural 5-HT1A response occurred in spite of misdevelopment of the olfactory bulb and hippocampus that is characteristic of Ncam–/– mice, and without an apparent change in the expression of 5-HT1A binding sites in the brain. Hippocampus- and amygdala-dependent learning, though disturbed in Ncam–/– mice, remained unaffected by the transgenic NCAM180. We suggest an involvement of NCAM180-mediated cell recognition processes in the serotonergic modulation of emotional behaviour in adult mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00197.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Differential effects of probucol on two distinct experimental rat nephrosis models (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We compared an antiproteinuric effect of a lipid-lowering agent probucol on two distinct types of experimental nephrosis in rats, i.e. mercuric–chloride (HgCl2)-induced autoimmune glomerulonephritis in Brown Norway (BN) rats and puromycin aminonucleoside (PA)-nephrosis in Wistar rats. The rats were fed either standard rat chow or chow containing 5% probucol. BN rats were treated with HgCl2 according to a standard protocol (HgCl2 1 mg/kg subcutaneously three times/week). Probucol treatment did not ameliorate proteinuria, renal histology or a strong linear staining for IgG and an intercellular adhesion molecule, ICAM-1, in glomeruli. Wistar rats were made nephrotic with an intraperitoneal injection of PA (100 mg/kg). In this model, in contrast to the BN rat model, no glomerular deposition of IgG or ICAM-1 was observed. Probucol treatment ameliorated proteinuria significantly. These findings suggest that the response to probucol differs in different experimental nephrosis models. As probucol only affects PA-nephrosis, in which ICAM-1 expression is negative, the ICAM-1 attenuation is not likely to be involved in the antiproteinuric effect of probucol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.00012.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cube Texture in Aluminum Single Crystal of a (118)[711] Orientation (1994)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 157-162 (May 1994), p. 541-546 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.157-162.541.pdf
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5 (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 626-631 
    Details
    ISSN: 1432-0533
    Keywords: C-series gangliosides ; Microtubule-associated protein 5 ; Fetal antigen ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistological study of Alzheimer's brains was performed using antibodies to C-series gangliosides and microtubule-associated protein 5 (MAP5), and their staining patterns were compared with those of antibodies to tau and β-amyloid precursor protein. Antibodies to C-series gangliosides and MAP5, both of which are known to preferentially expressed in the fetal brains, immunostained dystrophic neurites of senile plaques, neurofibrillary tangles and neuropil threads abundant in 3rd and 5th layers in the cerebral cortex, all of which are considered to be pathological hallmarks of Alzheimer's disease. The immunostaining patterns of these structures by antibodies to C-series gangliosides and MAP5 were similar to those by the antibody to tau. These three antibodies also immunostained some neurons in Alzheimer's brain, although their staining patterns were slightly different from one another; i.e., both diffuse and granular patterns were seen by the antibody to tau, but only granular pattern by the antibodies to C-series gangliosides and MAP5. These neurons immunostained by these three types of antibodies appeared to be the precursors of the classical neurofibrillary tangles, as positively stained neurons were not seen in the brains of non-demented cases. The presence of fetal antigens such as the C-series gangliosides and MAP5 in Alzheimer's brain may suggest that regeneration or sprouting of neurons is ongoing in association with the re-induction of gene expression characteristic for the brain in the early stage of development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296372
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 228-233 
    Details
    ISSN: 1434-9949
    Keywords: Stromelysin ; Rheumatoid Arthritis ; Osteoarthritis ; Serum ; Synovial Fluid ; Lansbury Index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stromelysin levels were measured using a one-step sandwich immunoassay in synovial fluid (SF) obtained from 31 patients with rheumatoid arthritis (RA) (31 samples) and 13 patients with osteoarthritis (OA) (13 samples) and in serum from 81 patients with RA (106 samples), 12 with OA (14 samples), 12 with gouty arthritis (gout) (14 samples), and 8 with osteoporosis (OP) (14 samples) to identify differences in the levels in these diseases as well as correlations with clinical parameters in RA. SF stromelysin levels were significantly higher in RA than in OA, and rose with increasing joint destruction in the former. No significant correlations were found between the SF stromelysin level in RA and various clinical parameters, except for the volume of SF which showed a correlation. Serum levels of stromelysin were highest in RA, gout, OA, and osteoporosis in decreasing order, and in RA were correlated with the Steinbrocker Stage. A significant correlation was also found between the serum stromelysin level and number of swollen joints, and correlations with the Lansbury index, ESR, CRP, WBC and Plt. The stromelysin level in SF was thought to be a useful parameter of local joint involvement and that in serum of the severity of systemic joint inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249017
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    Paper (German National Licenses)
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