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  • Articles: DFG German National Licenses  (2)
  • 2000-2004  (2)
  • 1970-1974
  • Midkine  (1)
  • WET model  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Key words Glial cytoplasmic inclusion ; Granule-coated fibril ; Midkine ; Multiple system ; atrophy ; Oligodendrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The glial cytoplasmic inclusion (GCI) is a histological hallmark for multiple system atrophy (MSA): these inclusions are found in oligodendrocytes and consist of abnormal granule-coated fibrils of approximately 24- to 40-nm diameter. To clarify the significance of the presence of midkine (MK) in these GCIs, we carried out immunohistochemical, electron and immunoelectron microscopical, and Western blot analyses of MSA brains using a monoclonal antibody against the C-terminal region of human MK. Immunohistochemically, most of the GCIs were intensely stained by the antibody to MK. Electron and immunoelectron microscopy showed that the GCIs were composed of MK-positive granule-coated fibrils that were essential constituents of these inclusions. No significant MK immunoreactivity was observed in oligodendrocytes, astrocytes and neurons of the normal control subjects. The presence of MK in MSA brain but not in normal brain was confirmed by Western blotting. Together with the fact that MK is associated with fetal morphogenesis during the midgestation period, the presence of MK immunoreactivity in oligodendroglial GCIs may suggest the existence of a repair mechanism on the basis of morphogenesis in the degenerated oligodendrocytes themselves as well as the affected neurons and their axons through the oligodendrocyte-axon-neuron relationship.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Flow, turbulence and combustion 63 (2000), S. 113-134 
    ISSN: 1573-1987
    Keywords: numerical analysis ; buoyancy ; WET model ; k-ε model ; thermal plume ; indoor air flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Turbulence models based on the eddy viscosity concept perform poorly for simulation of non-isothermal flows, which are characterized by strongly non-isotropic features of turbulence. In the present study, a thermal plume is calculated using the WET model and severalk-ε models. Comparison with the experiments reveals that the WET model predicts the flow and temperature fields most accurately. Furthermore, the WET model has been modified to account for the damping effect near the wall and applied to the indoor air flow. The computed flow field agrees well with the measurement, except for higher temperatures appearing near the walls.
    Type of Medium: Electronic Resource
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