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  • Articles: DFG German National Licenses  (25)
  • 2000-2004  (24)
  • 1940-1944  (1)
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  • Articles: DFG German National Licenses  (25)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 18 (2002), S. 193-219 
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Spindle microtubules interact with mitotic chromosomes, binding to their kinetochores to generate forces that are important for accurate chromosome segregation. Motor enzymes localized both at kinetochores and spindle poles help to form the biologically significant attachments between spindle fibers and their cargo, but microtubule-associated proteins without motor activity contribute to these junctions in important ways. This review examines the molecules necessary for chromosome-microtubule interaction in a range of well-studied organisms, using biological diversity to identify the factors that are essential for organized chromosome movement. We conclude that microtubule dynamics and the proteins that control them are likely to be more important for mitosis than the current enthusiasm for motor enzymes would suggest.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    Psychophysiology 38 (2001), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: One challenge in the analysis of event-related potentials (ERPs) is to identify task-related differences in scalp topography. The multivariate Partial Least Squares (PLS) analysis was used to identify the spatiotemporal distribution of ERP differences related to experimental manipulations. Two simulations included latency shifts and amplitude changes at peaks with temporal overlap. PLS identified effects only at modeled timepoints and electrodes. In contrast, principal components analysis identified differences at most timepoints. We also demonstrated that PLS identified combinations of waveform differences, not isolated sources. ERP components in an auditory oddball task were also assessed with PLS. The primary distinction was between ERPs on hit and correct rejection trials, expressed at multiple timepoints and electrodes. PLS provides a mechanism to describe experimental differences in ERP waveforms, simultaneously across the head.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    Psychophysiology 37 (2000), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Past research has demonstrated an age-related increase in the Stroop effect. Some theorists have suggested that this increase results from a decline in the ability to inhibit word information on incongruent trials, whereas others have suggested that the decline reflects general slowing. These two hypotheses were evaluated using event-related brain potentials (ERPs) measured while younger and older adults performed the Stroop task. As expected, the Stroop effect was greater for older than younger adults. The ERP data revealed a selective age-related attenuation of two modulations reflecting the inhibition of word information on incongruent trials. Latency of the P3 wave did not increase to a greater extend for older than younger adults from the congruent to incongruent trials as expected based on the general slowing hypothesis. Taken together, these findings support the inhibitory deficit hypothesis by demonstrating an age-related decline in a conceptual level inhibitory process that supports the suppression of word information in the Stroop task.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    Psychophysiology 41 (2004), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The anterior cingulate cortex (ACC) holds a prominent place in models of the neural architecture supporting cognitive control and conflict processing. The findings of empirical and computational work lead to the prediction that the ACC is sensitive to response conflict and insensitive to nonresponse conflict. We tested this prediction in two experiments using event-related brain potentials in combination with a task in which some trials included only nonresponse conflict and others included nonresponse and response conflict. A N450 associated with the activity of neural generators in the ACC and anterior frontal region was elicited on trials including only nonresponse and nonresponse and response conflict. This finding is inconsistent with the hypothesis that activation of the ACC is limited to response conflict and may identify one avenue of development in future applications of conflict theory.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aim  To examine whether exercise counselling increases smoking abstinence and reduces tobacco withdrawal and gains in weight and body fat.Design  A randomized controlled trial.Setting  A community-based stop smoking clinic.Participants  Two hundred and ninety-nine male and female smokers.Intervention  Participants were assigned randomly to a 7-week smoking cessation programme, including nicotine replacement therapy plus either (i) exercise counselling, or (ii) health education advice with equal contact time as for the exercise counselling condition.Measurements  Six weeks of smoking abstinence was confirmed by expired carbon monoxide.Findings  There was no significant difference in smoking abstinence between the exercise group (n = 154) and the controls (n = 145) at 6 weeks (39.6% versus 38.6%), nor was there any difference in gains in weight or body fat, although those in the exercise group increased their exercise levels. Exercise participants reported less tension, anxiety and stress than the controls during the first week of smoking abstinence (P = 0.03, 0.01 and 0.04, respectively), less irritability throughout 2 weeks of abstinence (P = 0.03), and less restlessness throughout 3 weeks of abstinence (P = 0.04).Conclusions  Adding brief exercise counselling to a smoking cessation programme did not increase smoking abstinence or reduce gains in weight or body fat significantly, although exercise levels were raised and there were some beneficial effects on psychological symptoms.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 96 (2001), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Objectives. Several countries have followed the US example in publishing national guidelines on smoking cessation interventions. Gauging responses to these guidelines can provide important lessons for future implementation and revision internationally. This study sought to assess General Practitioners' (GPs') views on recently published English smoking cessation guidelines that form the foundation of the UK National Health Service's smoking cessation strategy. Design. Postal survey in which GPs were asked to judge the appropriateness, effectiveness and practicability of key recommendations for primary care in recent national smoking cessation guidelines. Setting. General practice, England and Wales. Subjects. Random national sample of GPs; 236 GPs completed the questionnaire; effective response rate: 62%. Results. Only 16% of GPs accepted that all the recommendations in the guidelines were appropriate; 43% accepted that it was appropriate to check the smoking status of known smokers when they visit the surgery and only 30% thought it was practicable to advise smokers to stop at every opportunity. However, 77% of GPs thought that they should provide assistance for smokers wanting to stop; 74% believed that they should refer smokers to specialist services if appropriate and a similar proportion (77%) believed that it was appropriate to recommend nicotine replacement therapy. Conclusions. There was greater acceptance by GPs that they should assist smokers wanting to stop than that they should routinely monitor smoking status and give opportunistic advice to patients to stop. Given that opportunistic advice is a cornerstone of the national guidelines there is a need to find ways of reconciling what is being recommended and what GPs feel is appropriate.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 96 (2001), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 96 (2001), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Objective. To assess the prevalence of motivation and behaviours relating to smoking cessation and attempts at harm minimization and the stability of these over a 1-year period; to identify demographic, social, behavioural and psychological predictors of attempts to stop smoking and the success of these attempts. Design. Face-to-face interviews were carried out with a national sample of UK smokers in April/May 1996 with follow-up 1 year later. Subjects. The original response rate was 61% (1478 of 1911 adult smokers), and of these 1012 were followed-up 1 year later (68% of those who were originally contactable). Results. Thirty-one per cent of smokers reported making at least one quit attempt during the follow-up period and 17% made a quit attempt in the first 9 months of that period. Of these 29% were still not smoking at least 3 months later. Fifty-one per cent of smokers had tried to cut down in the year leading up to the first survey. There was a fair degree of consistency over time in individual smokers' desires and intentions to stop smoking across both surveys and in the incidence of quit attempts and attempts to cut down. Beliefs about the effects of smoking on future health and having a partner who disliked their smoking were positively associated with making a quit attempt at follow-up while reporting enjoying smoking at baseline was negatively associated with making a quit attempt at follow-up. Time to first cigarette of the day and age of starting smoking were positively associated with success of quit attempts. Conclusions. Motivation and behaviours relating to smoking cessation are prevalent and fairly stable over time. Different factors appear to be related to attempts to stop and the success of those attempts. Interventions to increase smoking cessation in the population should take account of this.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 96 (2001), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Objective. To evaluate the efficacy of a brief smoking cessation intervention with pregnant women practicable routinely by midwives. Design. Midwives were randomized to deliver the experimental intervention or usual care. The 10-15-minute intervention was based on brief counselling, written materials, arrangements for continuing self-help support and feedback on expired-air carbon monoxide levels. The intervention was tailored to the women's needs: those who did not want to stop smoking received a brief motivational intervention, those who wanted to stop received an intervention designed to assist them and those that had stopped recently (recent ex-smokers) received a relapse prevention intervention. Setting. Booking interviews with pregnant women in nine hospital and community trusts. Subjects. A total of 1120 pregnant women in the third month of pregnancy (249 recent ex-smokers and 871 current smokers). Main outcome measures. Three indicators of biochemically validated abstinence were collected. Continuous abstinence for at least 3 months prior to delivery, point prevalence abstinence immediately post-delivery, and continuous abstinence from 3 months pre-delivery to 6 months post-delivery. Results. Only a small proportion of the women who would have been eligible to take part in the trial were actually recruited by 178 recruiting midwives, with lack of time being cited as the main barrier. The intervention and usual care groups differed in post-delivery point prevalence abstinence rates for recent ex-smokers (65% vs. 53%, p 〈 0.05, one-tailed), but not in other outcome measures. Overall, 54% of 'recent ex-smokers' at booking and 7% of 'current smokers' at booking had been abstinent for at least 3 months at the time of delivery, and 23% and 3%, respectively, were still abstinent by the time the child was 6 months old (i.e. 12 months post-intervention). Smoking status at follow-up was predicted by dependence indexed by time to first cigarette in the morning . Conclusions. A brief 'one-off' smoking cessation intervention by midwives does not seem to be a practicable or effective method of helping pregnant smokers to stop. Other options such as tailored self-help materials and telephone counselling and other specialist treatments should be examined. Current smoking cessation rates in pregnancy are very low.
    Type of Medium: Electronic Resource
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