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  • Articles: DFG German National Licenses  (3)
  • 2000-2004  (1)
  • 1880-1889  (2)
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  • Articles: DFG German National Licenses  (3)
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Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Differential activation of signal transducer and activator of transcription 6 in B cells from allergic children and their non-allergic siblings (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The germline (GL) ɛ promoter is regulated by IL-4 and is essential for class switching to IgE. IL-4-induced gene expression is largely mediated through activation of latent transcription factor STAT6 (signal transducer and activator of transcription 6).Objective We investigated whether increased levels of IgE in allergic individuals may be associated with alteration in the level or activation of STAT6 and subsequent increase in GL ɛ promoter activity.Methods Electrophoretic mobility shift assay and Western blotting assays were used to investigate the level of expression and activation of STAT6 in Epstein–Barr virus (EBV)-transformed B cell lines from children with birch pollen allergy and their non-allergic siblings. The activity of the GL ɛ promoter was tested in a transient transfection assay.Results STAT6 was expressed at the same level in all B cell lines tested. In two out of five sibling pairs STAT6 was activated by IL-4 more efficiently in the allergic individuals but in the three other pairs the opposite was found. In transient transfections, no difference in IL-4-induced GL ɛ promoter function was detected, although basal promoter activity varied between allergic and healthy siblings in two out of five pairs.Conclusions We demonstrate for the first time that upon IL-4 signalling STAT6 transcription factor activation differs in B cells from different individuals. Although we did not find any association between STAT6 activation and allergy, we do not exclude a possibility that stronger activation of this transcription factor is associated with an expression of allergic phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.1911.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Bakterien der Schweineseuche (1884)
    Springer
    Virchows Archiv 95 (1884), S. 468-484 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01880531
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Cambridge Cholera Fungus (1886)
    [s.l.] : Nature Publishing Group
    Nature 35 (1886), S. 171-172 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN NO. 247, vol. xli. of the Proceedings of the Royal Society, just published, there is a preliminary report on the pathology of cholera asiatica, by Messrs. C. Roy, J. Graham Brown, and C. S. Sherrington, in which these gentlemen describe and figure the occurrence, in the tissue of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/035171a0
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    Paper (German National Licenses)
    Fulltext
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