ISSN:
1432-1971
Keywords:
Key words: Cardiac index — Congenital heart disease — Nitric oxide — Tumor necrosis factor-α
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. We wished to determine the relationship between circulating levels of nitric oxide (NO) and cardiac index (CI) in children with congenital heart diseases. We measured the plasma levels of nitrate/nitrite (NO x ), the stable end products of NO production as well as tumor necrosis factor-α (TNF-α), atrial natriuretic peptide (ANP), and brain natriuretic peptide in relation to various parameters determined simultaneously. The plasma NO x levels correlated negatively with CI (r=−0.541, p 〈 0.05). No correlation was observed between NO x and cardiac output. TNF-α correlated with NO x levels (r= 0.593, p 〈 0.005) but not with either CI or cardiac output. Plasma levels of ANP and TNF-α were higher in atrial septal defect than those in the control group (p 〈 0.001 and p 〈 0.05, respectively). Elevated plasma NO x could explain the increased basal release of endothelial NO due to high pulmonary blood flow. Plasma NO x correlate negatively with CI in young patients with left-to-right shunt congenital heart diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002460010086
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