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  • Articles: DFG German National Licenses  (2)
  • 2000-2004  (2)
  • Key words Phentolamine  (1)
  • Key words Rheumatoid arthritis  (1)
  • 1
    ISSN: 1432-1238
    Keywords: Key words Phentolamine ; Measurement techniques ; Glucose ; Indocyanine green ; Fluid redistribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: We have recently reported that the initial distribution volume of glucose (IDVG) reliably measures the central extracellular fluid (ECF) volume in the presence of fluid gain or loss. However, it is not clear if IDVG consistently reflects central-ECF volume when redistribution of fluid occurs in the absence of fluid gain or loss. This study was designed to investigate changes in fluid volumes during phentolamine infusion in dogs. Design: Prospective animal study. Setting: Institutional animal research laboratory. Subjects: Fourteen anesthetized and ventilated mongrel dogs. Interventions: Anesthetized animals were mechanically ventilated and received infusions of normal saline (n = 7) or phentolamine (10 μg kg min) (n = 7). Plasma volume was estimated using the indocyanine green (ICG) dilution method (PV-ICG) and IDVG was calculated using a one-compartment model by simultaneous administration of ICG 0.5 mg/kg and glucose 100 mg/kg before, during, and after infusion of either drug. Measurements and results: PV-ICG during infusion was not different between groups. However, IDVG significantly decreased (P 〈 0.05) following phentolamine infusion when compared with normal saline infusion. Conclusion: Our results suggest that IDVG rather than PV-ICG consistently measures central extracellular fluid volume, even when redistribution of fluid occurs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Modern rheumatology 10 (2000), S. 155-159 
    ISSN: 1439-7609
    Keywords: Key words Rheumatoid arthritis ; Wrist ; Orthosis ; Distal radioulnar joint ; Compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One of the wrist orthoses, the Senami Wrist Supporter (SWS), was applied to 203 rheumatoid wrists in 112 patients who had persistent wrist pain and restricted forearm rotation due to synovitis and instability at the distal radioulnar joint (DRUJ). The study was performed by sending out a questionnaire to the patients about the use of the SWS at home, and examining grip strength and forearm rotation with and without the use of the SWS. The average age of the patients was 61 years, and the average follow-up period was 18 months. The rate of compliance of wearing the SWS at home was 73% on average. It was higher in wrists of Larsen–Dale–Eek (LDE) grades 0, I, and II (normal, slight, and definite early abnormality) than in those of grades III, and IV (medium and severe destructive abnormality). Decreased pain was noted in 52% of the wrists at the time of applying the SWS. The SWS was not used in 10% of the wrists because of remission of pain at follow-up. Grip strength increased significantly (P 〈 0.01) and so did forearm rotation (P 〈 0.05) by the stabilizing effect of the SWS on the unstable DRUJ. The use of the SWS was confirmed to be an efficient measure to treat painful rheumatoid wrists with early stages of disease at the DRUJ.
    Type of Medium: Electronic Resource
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