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Acoustic observation of diel vertical migration and shoaling behaviour in Atlantic redfishes (2002)

Gauthier, S. ; Rose, G. A.

Oxford, UK : Blackwell Publishing Ltd

Journal of fish biology 61 (2002), S. 0

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ISSN: 1095-8649

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Acoustic methods were used to study Atlantic redfishes Sebastes spp. vertical migration and shoaling behaviour in Newfoundland waters. Redfishes exhibited consistent patterns of vertical migration in winter, spring and summer, but pelagic shoals were not observed in winter. Pelagic daytime aggregations were generally in close proximity to dense patches of redfishes along the sea floor. Pelagic shoals exhibited high degrees of variability in size, shape and density. Attempts to explain variations in shoal density and area with features of shoal position and structure were unsuccessful. Nearest neighbour distance between fish in shoals had a lower limit near one body length. During the night, fishes were dispersed in the water column and distributions were more homogenous. Diel vertical migration appeared to be a foraging strategy, in which redfishes followed the migration of their euphausiid prey.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1095-8649.2002.tb02461.x

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Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma (2000)

Belpomme, D. ; Gauthier, S. ; Pujade-Lauraine, E. ; [et al.]

Springer

Annals of oncology 11 (2000), S. 1471-1476

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ISSN: 1569-8041

Keywords: 5-FU continuous infusion ; metastatic breast carcinoma ; multidrug resistance ; verapamil

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Background:Verapamil (VER), a potent calcium channel blocker, hasbeen found to overcome P-gp-mediated multi-drug resistance (MDR) and toincrease sensitivity to cytotoxic anticancer drugs in refractory myeloma andnon-Hodgkin lymphoma. The value of VER for treating solid tumors is still amatter for debate. Patients and methods:We performed a prospective study in 99patients with anthracycline-resistant metastatic breast carcinoma (MBC), toassess the clinical effect of oral VER given in association with chemotherapy.Instead of retreating patients with anthracycline, we used a partiallynoncross-resistant regimen (VF), combining vindesine (VDS) and 5-fluorouracilgiven as a continuous infusion (5-FU CI). Patients were randomly assigned totwo cohorts. One cohort (47 patients) was treated in 28-day cycles, eachinvolving the administration of VDS (3 mg/m2 i.v. bolus on days 1and 10) and 5-FU CI, (400 mg/m2/day i.v. from day 1 to day 10). Theother cohort (52 patients) received the same VDS and 5-FU treatment and anadditional oral VER treatment (240 mg/day divided in 2 doses), from day 1 today 28 of each cycle. Patients were treated until progression. Results:The treatment was well tolerated and no side effects thatcould be attributed to VER were detected. Patients treated with VER had longeroverall survival (OS) (median OS: 323 vs. 209 days, P = 0.036) anda higher response rate (27% vs. 11%, P = 0.04) thanthose not given VER. Progression-free survival (PFS) was also longer but thedifference was not statistically significant (median PFS: 4.6 and 2.7 monthsfor the VER and non-VER groups respectively, P = 0.6). Conclusions:This clinical trial demonstrates that achemosensitizer, such as VER, can increase the survival of MBC patients withacquired anthracycline resistance.