ISSN:
1437-2320
Keywords:
Key words 11C-methionine
;
PET
;
PCNA
;
Glioma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract 11C-methionine positron emission tomography (PET) and proliferating cell nuclear antigen (PCNA) staining were performed in 13 cases of glioma to investigate the relationship between the uptake of l-[methyl]-11C-methionine and the degree of malignancy and proliferative potential. The 11C-methionine uptake was significantly greater in high-grade gliomas compared to low-grade gliomas (P〈0.05). The PCNA indexes were also significantly higher in the high-grade cases (P〈0.05). Moreover, a strong positive correlation was found between the 11C-methionine values and the PCNA indexes (P〈0.005), demonstrating that higher 11C-methionine uptake was associated with greater proliferative potential and greater malignancy. 11C-methionine PET is a potentially useful preoperative method to discriminate the malignacy of glioma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s101430050018
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