ISSN:
1612-1112
Schlagwort(e):
Column liquid chromatography
;
Circular dichroism detection
;
Multiscan detection
;
Peak purity
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Summary A method has been developed to detect inhomogeneity of apparently homogeneous peaks of very similar analytes. The method utilizes the rapid scan feature of state-of-the-art spectrometers/detectors that allow the recording of up to 30 spectra in a single chromatographic peak. Sensitivity and selectivity are enhanced by chiroptical/optical detection. Thus, identification of “front” and “rear” components of the peak can be carried out. The method is exemplified by mixtures of codeine, hydrocodone and oxycodone as analytes.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02466654
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