ISSN:
1432-0584
Keywords:
Key words Lupus anticoagulants
;
Platelet antibodies
;
Antiphospholipid antibodies
;
Thromboembolism
;
Thrombocytopenia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We have studied target platelet antigens in 22 patients with lupus anticoagulants and a primary antiphospholipid syndrome in order to determine whether any specificities of platelet autoantibodies are correlated with thromboembolism, and if these antibodies cross-reacte with phospholipids, which would suggest their role in the development of thromboembolic disease. Platelet counts were median 203×109/l, range 100–298×109/l. Platelet antibodies were found in six thrombocytopenic patients and in further nine patients. All these 15 patients had antibodies against GPIIb/IIIa, five patients against GPIb/IX, and six patients against GPIV. Anti-GPIb/IX and -GPIV occurred only in combination with anti-GPIIb/IIIa antibodies. There was no correlation between the presence of detectable platelet antibodies or any of their glycoprotein specificity and thrombocytopenia or the history of a thromboembolic disease. Eluates from platelets contained only GPIIb/IIIa reactivities, but neither anti-GPIb/IX nor anti-GPIV. None of the eluates contained lupus anticoagulant activity. In one case, the platelet eluates contained anti-GPIIb/IIIa and anticardiolipin IgG antibodies. These results suggest that in patients with a primary antiphospholipid syndrome the presence of platelet autoantibodies neither indicate a risk for thromboembolic disorder nor have lupus anticoagulant activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050291
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