ISSN:
0009-2940
Schlagwort(e):
Arene Complexes
;
Ruthenium
;
Diastereoselective
;
Reduction
;
Chemistry
;
Inorganic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Two preparative routes are reported that give access to the racemic series of planar chiral [(arene)(COD)Ru] derivatives containing η6-bonded o-tolyl ketone or aldehyde arene units. The ketone and aldehyde functions of these have subsequently been reduced by nBuLi and PhLi, respectively. Hydrolysis converts the initially formed lithium salts into diastereomeric benzyl alcohol complexes lithium salts into diastereomeric benzyl alcohol complexes in high yields. The formation of the new stereogenic centre is diastereoselective (88% de) for the aldehyde and diastereospecific for the ketone (de 〉 99%). Due to a sterically overcrowded situation, the rotation of the chiral side chain of [(COD) (η6-o-tolyl-tert-butylphenylmethanol) Ru] (7) is hindered, as is the rotation of the phenyl and tert-butyl substituents. As a consequence, the hydroxyl group is fixed at a position close to the metal both in solution and in the solid state.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/cber.19971300923
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