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  • 11
    Electronic Resource
    Electronic Resource
    Occurrence of enzymes of free radical metabolism suggests the possible cytotoxic capacity of the transitional epithelium of the human ureter (1997)
    Springer
    Cell & tissue research 287 (1997), S. 351-356 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Urothelium ; Tartrate-resistant acid phosphatase ; Nitric oxide synthase I ; Superoxide dismutase ; Immunocytochemistry ; Free radicals ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Three enzymes, viz., tartrate-resistant acid phosphatase (TRAP), nitric oxide synthase I (NOS-I), and superoxide dismutase (SOD), involved in the production and metabolism of free radicals or radical equivalents, were demonstrated by immunocytochemistry in the urothelium of the ureters of six patients of various ages. Two of these enzymes (TRAP and NOS-I) were colocalized in the most apical and lateral border of the superficial cells of the urothelium. In contrast, SOD showed a patchy or granular distribution within the supranuclear region of these cells. Intra- and subepithelial macrophages exhibited a weak TRAP, but no NOS-I or SOD, immune reaction. On the basis of the immunocytochemical findings, arguments in favor of a cytotoxic function of the superficial cells of the human urothelium are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050760
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  • 12
    Electronic Resource
    Electronic Resource
    Diagnostik und Therapie der hämorrhagischen Diathese in der perioperativen Situation (1999)
    Springer
    Gefässchirurgie 4 (1999), S. 5-12 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Blutungsneigung ; Hämorrhagische Diathese ; Erworbene und angeborene Thrombopathien ; Plasmatische Gerinnungstörungen ; DDAVP ; Key words Bleeding tendency ; Hemorrhagic diathesis ; Acquired and congenital qualitative platelet disorders ; Blood coagulation disorders ; Deamino-d-arginine vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In surgical procedures associated with high blood loss, such as vascular and cardiac operations, differential diagnosis and therapy of perioperative hemorrhage are of special importance. Preoperative screening for patients at high risk of bleeding and in particular for those with qualitative platelet disorders [drug-induced platelet disorders (in particular ASS), von Willebrand's disease and other congenital platelet disorders] is effective in minimizing blood loss. Bleeding in acute medical emergencies or during emergency operations may require treatment without specific investigations being performed in advance. Therefore, simple schemes are essential for the rapid management of acute hemostatic problems. The aim of this paper was to address the diagnostic and therapy of hemorrhagic diathesis focusing mainly on diagnosis and therapy of hemorrhagic diathesis due to blood platelet disorders and blood coagulation disorders and preoperative identification of patients at increased risk of bleeding.
    Notes: Zusammenfassung Die Differentialdiagnostik und Therapie von perioperativen Blutungen besitzt in der Gefäß- und Kardiochirurgie bei Eingriffen mit hohen Blutverlusten einen besonderen Stellenwert. So ist es sinnvoll, Patienten mit einem erhöhten Blutungsrisiko bereits präoperativ zu erfassen und adäquat vorzubereiten. Insbesondere die präoperative Erfassung von Thrombopathien [medikamenteninduzierte Thrombopathien (insbesondere durch ASS), von-Willebrand-Jürgens-Syndrom, andere angeborene Thrombopathien] ist bei der Minimierung von Blutverlusten effektiv. Nicht elektive Situationen (Blutung bei Notoperationen, Akutpatienten) müssen oft ohne gezielte hämostaseologische Diagnostik rational therapiert werden. Einfache Schemata sind für ein schnelles Handeln unabdingbar. In dieser Arbeit soll versucht werden, Hinweise zu Diagnostik und Therapie der hämorrhagischen Diathese mit den Schwerpunkten: Diagnostik und Therapie der thrombozytär bedingten hämorrhagischen Diathese und Diagnostik und Therapie der plasmatisch bedingten hämorrhagischen Diathese aus hämostaseologisch-transfusionsmedizinischer Sicht zu vermitteln. Ein für den Routinebetrieb auf chirurgischen Stationen anwendbares Schema zur präoperativen Erfassung von Patienten mit erhöhtem Blutungsrisiko sowie erste Erfahrungen damit werden vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010539
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  • 13
    Electronic Resource
    Electronic Resource
    Solubility and molecular modeling of triflumizole-β-cyclodextrin inclusion complexes (1995)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 22 (1995), S. 15-32 
    Details
    ISSN: 1573-1111
    Keywords: β-Cyclodextrin ; triflumizole ; host-guest complex ; inclusion complex ; solvent accessible surface ; solubility enhancement ; hydrophobic effect ; dynamic Monte Carlo molecular docking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Solubility enhancement of the fungicide triflumicole byβ-cyclodextrin is explained using a thermodynamic approach. The influence of organic cosolvents on the overall equilibrium constants of triflumizole complexation withβ-cyclodextrin in aqueous solutions has been investigated. Their variance in mixed solvents is only partly explained by a competitive inclusion of substrate and cosolvent molecules inβ-cyclodextrin. The geometries of host-guest complexes have been estimated by molecular mechanics calculations. Their broad structural variety caused by the flexibility of host and guest molecules and different association possibilities of triflumizole have been analysed by a dynamic Monte Carlo docking method. The hydrophobic effect has been simulated by cominimization of the hydrophobic contributions to the solvation energy, calculated from the solvent accessible surface area of the complex and the conformational (potential) energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706495
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  • 14
    Electronic Resource
    Electronic Resource
    De novo expression of the cell adhesion molecule E-selectin on gastric cancer endothelium (1998)
    Springer
    Langenbeck's archives of surgery 383 (1998), S. 81-86 
    Details
    ISSN: 1435-2451
    Keywords: Key words Gastric cancer ; Vascular density ; Endothelial phenotype ; Vascular targeting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background and aims: Angiogenesis and the molecular phenotype of the tumor vasculature determine tumor growth and metastasis. Patients/Methods: In a series of 58 gastric cancer patients, vascular density and the antigenic profile of endothelial cells in normal, inflamed and malignant gastric tissues were compared using immunohistochemistry. Results: In both benign gastric mucosa and primary gastric cancer vascular density was inflammation-independent. However, increased vascularity in primary tumors was positively associated with a high tumor cell density suggesting tumor-induced angiogenesis (P=0.00001). P-selectin was expressed in most of the gastric mucosa samples on a small fraction of vessels and increased in the presence of moderate to strong leukocyte infiltrate. VCAM-1 positive mucosal vessels were rare and showed no association with inflammation. E-selectin and the EN 7/44 antigen defining budding vessels were absent on normal and inflamed endothelium. In contrast, in primary gastric cancer de novo expression of both E-selectin and the EN 7/44 antigen was observed. E-selectin positive vessels were preferentially found in vascular-rich tumor areas (P=0.0043) independently of leukocyte infiltration. Upregulation of VCAM-1 on tumor-associated endothelium was closely related to inflammation (P=0.019), while P-selectin expression resembled that in benign mucosa. Conclusions: Differentially expressed vascular molecules may influence the functional characteristics of extravasating leukocytes and represent new targets in anti-gastric cancer therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050096
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  • 15
    Electronic Resource
    Electronic Resource
    Biogeochemistry of Iron and Sulfur in Sediments of an Acidic Mining Lake in Lusatia, Germany (1998)
    Springer
    Water, air & soil pollution 108 (1998), S. 231-247 
    Details
    ISSN: 1573-2932
    Keywords: bacterial sulfate reduction ; iron reduction ; sediment ; pore-water chemistry ; acidic mining lake ; stable sulfur isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Chemical, microbiological and stable isotope analyses of sediments from an acidic mining lake were used to evaluate whether biogeochemical processes, such as iron and sulfate reduction, are extant, because such processes can potentially generate alkalinity. Sediment cores were sliced in cm intervals to achieve a high resolution for spatial distribution of organic and inorganic components. Iron, sulfur, carbon, nitrogen and phosphorus as well as the most probable number (MPN) of iron reducing bacteria, the amount of lipid phosphate and the stable isotope compositions of various sedimentary sulfur compounds were measured. Accumulation of degradable organic material, reduced mass fractions of iron, enhanced concentrations of lipid phosphate, high concentrations of DOC and ferrous iron in the pore water and a drastic change of sulfur isotope ratios in the upper 3 cm of the sediment all indicated a highly reactive zone of biogeochemical transformations. The data provide clear evidence for iron and sulfate reducing processes in the sediments that result in an increase of pH with depth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005195617195
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  • 16
    Electronic Resource
    Electronic Resource
    Structure and spectroscopic properties of cyclodextrin inclusion complexes (1996)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 25 (1996), S. 103-108 
    Details
    ISSN: 1573-1111
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We compare spectroscopic properties of higher order complexes of organic guests (e.g. naphthalene, phenols, indole, C60 fullerene) with cyclodextrins (CDx) to results of molecular modeling investigations. Naphthalene 1:2 complexes with α-CDx show high spectral resolution and peculiar triplet properties. Molecular simulations and calculation of the experimentally measured induced circular dichroism (ICD) provide detailed structural information.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01041546
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  • 17
    Electronic Resource
    Electronic Resource
    Der Leistungseintrag zur Charakterisierung und Maßstabübertragung von Bioprozessen aus Schüttelkolben (1995)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 67 (1995), S. 1111-1112 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330670946
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