ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Specific serum antibodies o the IgM. IgG and IgA classes against extracts from Bacteroides gingivalis, Bacteroides ureolyticus, Capnoc ytophaga ochracea, Eubacterium saburreum, Fusobacterium nucleatum and Selenomonas sputigena were measured by an enzyme-linked immunosorbent assay. The study groups were: (1) 15 renal transplant recipients, (2) 5 patients treated with hemodialysis, (3) 29 systemically healthy subjects with healthy periodontium and (4) 23 systemically healthy persons with chronic periodontitis. The renal patient groups showed significant evidence of alveolar bone loss, had abundant dental plaque, but significantly (p〈0.05) fewer bleeding gingival units and lower mean pocket depth than the periodontitis group. Two-way analyses of variance, comparing the renal patient groups with the healthy control group, showed statistically significant group effects for the specific IgG responsiveness during hemodialysis (F=4.94, p〈0.05) and the IgA responses in the renal transplant group (F=7.78. p〈0.05) (reduced values). As compared with the periodontitis group, the renal patient groups displayed significantly (p〈0.05) lower serum antibody concentrations against B. gingivalis. C. ochracea and F. nucleatum within at least 2 of the 3 immunoglobulin isotypes assayed. The results support the contention that some forms of periodontitis are mediated by prolonged low-grade local immune reactions which at times may escape homeostatic control.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1986.tb01491.x
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