ISSN:
1573-4935
Keywords:
pro-TGF-α cleavage
;
TGF-α secretion
;
autocrine
;
juxtacrine
;
A431
;
oesophageal SCC
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Transforming growth factor alpha (TGF-α) is a single chain polypeptide which exists in a variety of forms differing in molecular weight. These forms are variously present in normal and neoplastic cells. Of particular interest are TGF-α's well-known mitogenic properties. The transition from a normal to a neoplastic cellular state results from signalling defects that may depend upon,iter alia, abonormal levels of expression and secretion of TGF-α. It is known that the secretion of TGF-α may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF). Here, we compare the efficacy of these three agents in the elevation of TGF-α secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01122801
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