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  • Articles: DFG German National Licenses  (25)
  • 1990-1994  (19)
  • 1920-1924  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Role of cytokines and inflammatory mediators in tissue destruction (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Colonization or emergence of microbial pathogens may result in tissue destruction by activation of one or more of five distinct host degradative pathways (matrix metalloproteinase pathway, plasminogen-dependent pathway, phagocytic pathway, PMN-serine proteinase pathway and osteoclastic bone resorption) or by direct cleavage of extracellular matrix constituents by microbial proteinases. Activation of endogenous destructive pathways may be mediated by immune responses resulting in expression of degradative cellular phenotypes among both immigrant and resident cell populations. In addition, expression of degradative phenotypes may be triggered by direct influences on host cells of microbial products (LPS, enzymes, toxins). A body of evidence suggests that each of these mechanisms involves local production of proinflammatory cytokines and growth factors. The matrix metalloproteinase pathway is centrally involved in dissolution of all unmineralized connective tissues and perhaps in resorption of bone as well. The matrix metalloproteinase family consists of nine or more genetically distinct Zn++ endopeptidases which collectively cleave all of the constituents of the extracellular matrix. Recent studies have uncovered many essential elements of a complex, but still incomplete, regulatory network that governs tissue destruction. Proinflammatory cytokines and growth factors induce signalling pathways several of which are dependent on protein kinase C and result in transient expression of the transcription factors c-jun and c-fos. Initiation of transcription of most matrix metalloproteinase genes requires binding of the transcription factor AP-1 (c-jun/c-fos) to a specific promoter sequence but attainment of maximal transcription rates is dependent on interaction with other promoter elements as well. Several matrix metalloproteinases have been detected in crevicular fluids and tissues of inflamed human gingiva as have the proinflammatory cytokines (IL-1 and TNF-α) which regulate their transcription. Although the mere presence of enzymes and cytokines does not necessarily impart function per se, these observations suggest that some level of spatial or temporal linkage exists between metalloproteinase/cytokine expression and gingival inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb02113.x
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  • 2
    Electronic Resource
    Electronic Resource
    A Putative New Retrovirus Associated with Multiple Sclerosis and the Possible Involvement of Epstein-Barr Virus in This Disease (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb38903.x
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  • 3
    Electronic Resource
    Electronic Resource
    Ultraviolet light induction of peripheral granulocytosis with splenomegaly: protection of mice with topical p-aminobenzoic acid (PABA) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 125 (1991), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Hairless mice were exposed to UVB irradiation from a Philips T1 12 light source. Mice that were exposed to UV-light and not protected with 5%p-aminobenzoic acid (PABA) showed a significantly higher number of peripheral blood granulocytes (P〈0·001) and a significantly higher mean weight of both the spleen and the liver (P〈0·001) than the non-irradiated controls. light microscopy of the histology of the enlarged liver and spleen showed a proliferation of granulocytes and the reticuloendothelial cells. Treatment with topical PABA during the whole period of UV-exposure prevented the peripheral blood granulocytosis. These protected mice also had a significantly (P 〈0·001) lower mean weight for the liver and spleen than UV-exposed and non-protected mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1991.tb14744.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Optical Spectrum of Hafnium (1923)
    [s.l.] : Nature Publishing Group
    Nature 112 (1923), S. 900-901 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a letter to NATURE of October 27, p. 618, in which we gave a complete list of the lines belonging to the hafnium spectrum between 2500 and 3500 Å.U., we announced a detailed examination of the remaining part of the spectrum which can be obtained photographically. The result of this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/112900b0
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  • 5
    Electronic Resource
    Electronic Resource
    The Optical Spectrum of Hafnium (1923)
    [s.l.] : Nature Publishing Group
    Nature 111 (1923), S. 322-322 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DURING the progress of the work of Coster and Hevesy on the concentration and isolation of the new element hafnium (atomic number 72), the discovery of which was announced in NATURE of January 20, p. 79, we have examined spectroscopically a large number of their preparations in order to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/111322a0
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  • 6
    Electronic Resource
    Electronic Resource
    On Urbain's Celtium Lines (1923)
    [s.l.] : Nature Publishing Group
    Nature 111 (1923), S. 461-461 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a previous letter (NATURE, March 10, p. 322) we have shown that the optical spectrum of the new element hafnium, of atomic number 72, which was discovered a short time ago by Coster and Hevesy, does not contain any of the lines belonging to the characteristic spectrum ascribed by Urbain ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/111461a0
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  • 7
    Electronic Resource
    Electronic Resource
    Small universal covers for sets of unit diameter (1992)
    Springer
    Geometriae dedicata 42 (1992), S. 205-213 
    Details
    ISSN: 1572-9168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The current smallest convex universal cover for sets of unit diameter is described. This reduction of Sprague's cover is by 4 · 10-11 and results in an asymmetrical cover. Another small universal cover of sets of unit diameter with an axis of symmetry reduces Sprague's cover by 0.0019. An indication is given of how to use computers in the solution of this kind of problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00147549
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  • 8
    Electronic Resource
    Electronic Resource
    An evaluation of fed-batch cultivation methods for mammalian cells based on model simulations (1993)
    Springer
    Bioprocess and biosystems engineering 9 (1993), S. 205-213 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Fed-batch cultivations of hybridoma cell cultures for antibody production were computer simulated by a detailed structured model, that divides the cell mass into four metabolic compartments and makes use of descriptions of the most important metabolic pathways. Surprisingly the simulations indicate, that online or frequent off-line control of fed-batch hybridoma cultures may lead to low and variable yields of antibody product. With less frequently controlled fed-batch cultures the system is more stable; and there is an optimal time interval for control, that depends on the feeds selected. The product yields in optimal fed-batch cultivations, however, are seldom higher than in comparable batch cultivations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369404
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  • 9
    Electronic Resource
    Electronic Resource
    The inhibiting effect of PABA on photocarcinogenesis (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 38-41 
    Details
    ISSN: 1432-069X
    Keywords: PABA ; Sunscreening agent ; Ultraviolet carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p〈0.05) and reduced both tumor yield and carcinoma yield (p〈0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505643
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  • 10
    Electronic Resource
    Electronic Resource
    Extra- and intracellular amino acid concentrations in continuous Chinese hamster ovary cell culture (1994)
    Springer
    Applied microbiology and biotechnology 41 (1994), S. 560-564 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A recombinant DNA Chinese hamster ovary (CHO) cell line that produces tissue-type plasminogen activator (tPA) was cultivated continuously in suspension with a constant dilution rate of 0.5 day with three different asparagine concentrations in the feed (0.05, 2.55 and 7.55 mm). The up-shift in asparagine concentration caused an up-shift in asparagine consumption [15.7 and 31.4 nmol (106 cells)−1 h−1] and intracellular concentration (2.19 and 18.7 mm). The up-shift was accompanied by an increased production of ammonium, glycine and alanine, and a metabolic shift whereby the cells began to produce aspartate and glutamate, which were consumed before the shift. The tPA production was reduced in the up-shift culture. This might be explained by ammonium inhibition, but alternatively by a surprising down-shift in the intracellular concentration of many amino acids, a down-shift that was not observed in the extracellular concentrations or consumption rates. For efficient physiological engineering of mammalian cells it is necessary to include both extracellular and intracellular measurements and to consider the transport into and out of the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178489
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