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  • Articles: DFG German National Licenses  (5)
  • 1990-1994  (5)
  • Immunohistochemistry  (3)
  • Malignant mesothelioma  (2)
  • Adults  (1)
Source
  • Articles: DFG German National Licenses  (5)
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    Localization of thromboxane synthase in human tissues by monoclonal antibody Tü 300 (1992)
    Springer
    Virchows Archiv 421 (1992), S. 249-254 
    Details
    ISSN: 1432-2307
    Keywords: Thromboxane ; Thromboxane synthase ; Immunohistochemistry ; Mononuclear phagocyte system ; Epithelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the monoclonal antibody Tü 300 we localized thromboxane synthase, a secondary enzyme of the arachidonic acid cascade, employing the alkaline phosphatase anti-alkaline phosphatase method and indirect double labelling immunofluorescence in frozen sections of human tissues. Aside from platelets, the source of the antigen, all cells of the mononuclear phagocytic system were positive, including epithelioid cells and associated giant cells, starry sky macrophages, dendritic cells of T-cell areas, Langerhans cells and Kupffer cells. In addition, some epithelial cells such as epithelia of tonsillar crypts, reticular epithelia of the thymic cortex and ductular epithelia in liver, pancreas, female breast and salivary glands showed occasional focal reactivity for thromboxane synthase. We suggest that the mAb Tü 300 is a key marker for the macrophage system and the thromboxane generating system in normal and pathological conditions. It may detect functional activities of as yet unknown significance in some specialized epithelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611182
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diagnostic tools for differentiating pleural mesothelioma from lung adenocarcinoma in paraffin embedded tissue (1993)
    Springer
    Virchows Archiv 423 (1993), S. 493-496 
    Details
    ISSN: 1432-2307
    Keywords: Malignant mesothelioma ; Lung adenocarcinoma ; Immunohistochemistry ; Expert system ; Discriminant analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A panel of 14 antibodies (panepithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu-M1, HEA-125, anti-carcinoembryonic antigen, anti-blood group-related antigens A, B, H, B72.3, antiplacental alkaline phosphatase, anti-vimentin and BMA-120), which have been evaluated for use in differentiating mesothelioma from lung adenocarcinoma, was applied to a group of 24 suspected mesotheliomas. Using the established qualitative, descriptive criteria derived from monovariate statistical analysis of the tumour control groups (definite mesotheliomas, adenocarcinomas), a definitive allocation was possible in only 25% of suspected cases. We therefore constructed two “expert systems”, based on multivariate discriminant analysis with either the ALLOC 80 program for ordinal data or a newly developed analysis program for binomial data. With these two systems diagnostic allocation of suspected mesotheliomas was improved to 75% and 79%. The use of binomial data (“positive” versus “negative”) in conjunction with the probability-based test system is of particular interest because the primary data are easy to record and the test results have a higher statistical probability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606540
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Diagnostic tools for differentiating between pleural mesothelioma and lung adenocarcinoma in paraffin embedded tissue. Part I: immunohistochemical findings (1993)
    Springer
    Virchows Archiv 423 (1993), S. 19-27 
    Details
    ISSN: 1432-2307
    Keywords: Malignant mesothelioma ; Lung adenocarcinoma ; Ber-EP4 ; BMA-120 ; Blood-group-isoantigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Specimens of 27 histologically definite mesotheliomas and 34 proven adenocarcinomas were examined with a panel of 14 antibodies: pan-epithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu-M1, HEA-125, anti-carcino-embryonic antigen (CEA), anti-blood group-related antigens (anti-BGR A, B, H), B 72.3, anti-placental alkaline phosphatase (PLAP), anti-vimentin and BMA-120 used to determine their value in the differentiation between pleural mesothelioma and lung adenocarcinoma. Lu-5, anti-cytokeratin-7 and -18, B 72.3 and PLAP reacted in a high percentage of cases with both mesothelioma and adenocarcinoma. Anti-CEA and anti-Leu-Ml did not react with any of the 27 mesotheliomas tested but showed a reaction in 75% (anti-CEA) and 66% (anti-Leu-M1) of the lung adenocarcinomas. Seventeen percent of the adenocarcinomas and 96% of the mesotheliomas showed a positive reaction with anti-vimentin. Ber-EP4 was demonstrated in all lung adenocarcinomas, but only in 2 mesotheliomas in a focal manner (7%). HEA-125 and anti-BGR A, B, H reacted with 83% (HEA-125) and 75% (anti-BGR A, B, H) of the lung adenocarcinomas. The statistical parameters, sensitivity and efficiency were estimated and a normogram for judging the diagnostic power of a single antibody for the differential diagnosis of mesothelioma versus adenocarcinoma was developed. According to this, Ber-EP4, HEA-125, anti-BGR A, B, H and anti-CEA were, in descending order, the most powerful discriminatory antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606427
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cardiac myxomas: Immunohistochemical study of benign and malignant variants (1991)
    Springer
    Virchows Archiv 418 (1991), S. 485-491 
    Details
    ISSN: 1432-2307
    Keywords: Cardiac myxoma ; Immunohistochemistry ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigens (neuron-specific enolase) in all tumour cells. Factor VIII was found in the endothelial cells of capillaries only. In the subendocardium of fetal heart tissue close to the foramen ovale myofibroblasts reacting with the panepithelial antibody lu-5 were detected. We conclude that CMs are neoplasms that may develop from embryonic cell remnants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606497
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Das Normgewicht des Gehirns beim Erwachsenen in Abhängigkeit von Alter, Geschlecht, Körpergröße und Gewicht (1994)
    Springer
    Der Pathologe 15 (1994), S. 165-170 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Normales Hirngewicht ; Erwachsene ; Alter ; Geschlecht ; Körpergröße ; Gewicht ; Key words Normal brain weight ; Adults ; Age ; Sex ; Height ; Weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based on more than 8000 autopsies of male and female patients without brain diseases the normal brain weight of adult males and females in relation to sex, age, body-weight, and body-height as well as Body Mass Index were calculated. The average brain weight of the adult male was 1336 gr; for the adult female 1198 gr. With increasing age, brain weight decreases by 2.7 gr in males, and by 2.2 gr in females per year. Per centimeter body height brain weight increases independent of sex by an average of about 3.7 gr. Body Mass Index is of minor importance and only relevant in males. Based on these data the independent variables, age and height, were for the first time combined in a nomogram for the calculation of brain weight. The mathematical functions were integrated in a computer program which facilitates the calculation of normal brain weights in individual cases.
    Notes: Zusammenfassung Anhand von über 8000 Autopsien von Patienten ohne Hirnkrankheiten wurden die Normgewichte der Gehirne für Männer und Frauen in Abhängigkeit von Alter, Körpergröße, Gewicht und Body Mass Index berechnet. Das Hirngewicht des erwachsenen Mannes beträgt im Durchschnitt 1336 g, das der erwachsenen Frau 1198 g. Pro Altersjahr nimmt das Hirngewicht beim Mann um ca. 2,7 g, bei der Frau um ca. 2,2 g ab. Pro cm Körpergröße nimmt das Hirngewicht bei beiden Geschlechtern um ca. 3,7 g zu. Den geringsten Einfluß auf das Hirngewicht hat der Body Mass Index, der praktisch nur bei Männern bedeutsam ist. Aus den unabhängigen Variablen, Alter und Körpergröße, wurde erstmals ein Nomogramm für das zu erwartende Hirngewicht konstruiert. Gleichzeitig wurden die Funktionen unter Berücksichtigung der wichtigsten Einflußgrößen in ein Computerprogramm integriert, das die Normgewichte errechnet und quantitative Aussagen über die Abweichung des Hirngewichts von der Norm im Einzelfall erlaubt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050040
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    Paper (German National Licenses)
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