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  • 1
    ISSN: 1432-1971
    Keywords: Age ; Heart rate variability ; Spectral analysis ; Cholinergic ; Adrenergic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We compared heart rate variability measures of 11 normal children (4–12 years) to 23 normal adults (21–43 years) to study the effect of age on heart rate variability measures. Children had a significantly higher supine and standing heart rate and lower supine and standing systolic diastolic blood pressure. Children also had a significantly higher supine standard deviation of HR, supine low frequency (0.01–0.05 Hz) (p〈0.005), supine high frequency (0.2–0.5 Hz) (p〈0.001), and standing high frequency powers (p〈0.005) compared to adults. The ratio of mid frequency (0.07–0.15 Hz) to high frequency power (0.2–0.5 Hz) upon standing was significantly lower in children (p〈0.005). While there was a significant increase of the mid frequency power from supine to standing posture in the adult group (p〈0.02), there was no such significant increase in children. There were also significant negative correlations between age and supine low frequency, mid frequency, and high frequency powers, and standing high frequency power. These findings illustrate a decrease of cholinergic and an increase of adrenergic modulation of heart rate variability with age (4–43 years).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. S33 
    ISSN: 1432-1076
    Keywords: Amino acid chromatography ; Renal transport defects ; Unusual amino acids ; Decreased plasma concentrations ; Methionine intolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The analysis of amino acids is the most frequently applied technique in the selective screening of inborn errors of metabolism. When urine is used as a starting material, simple techniques such as thin-layer chromatography or highvoltage electrophoresis is preferred as a first approach. The quantitative analysis requires instrumentation, usually an amino acid analyser. Both plasma and urine are needed for establishing renal transport defects. Apart from the accumulation of the ‘usual’ amino acids, the presence of unusual amino acids may be of diagnostic significance. Furthermore the finding of decreased plasma concentrations of specific amino acids may pinpoint several inherited defects. No amino acid screening procedure is complete without the availability of an organic acid and a purine/ pyrimidine analytical system, both yielding important additional diagnostic information. Considerable clinical problems may occur in subjects with a decreased tolerance to protein amino acids without being homozygous for any inherited defect. Examples of these disorders that need further studies are homocysteinaemia associated with vascular disease and carriers of ornithine transcarbamylase deficiency.
    Type of Medium: Electronic Resource
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