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  • Articles: DFG German National Licenses  (1)
  • 1990-1994  (1)
  • Negative cooperativity  (1)
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  • Articles: DFG German National Licenses  (1)
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  • 1990-1994  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels (1993)
    Springer
    European biophysics journal 22 (1993), S. 1-4 
    Details
    ISSN: 1432-1017
    Keywords: Potassium channel ; Channel blockage ; Hill coefficient ; Negative cooperativity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Blockage of ATP-sensitive K+ channels by various drugs has been reported to exhibit a weak concentration dependence with Hill coefficients below unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the drug affinities of neighbouring channels. Results are presented for a dimeric and a tetrameric channel model and compared with published experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205806
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