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  • Articles: DFG German National Licenses  (2)
  • 1990-1994  (2)
  • Osteoarthritis  (1)
  • Trametes versicolor  (1)
  • 1
    ISSN: 1476-5535
    Keywords: Siderophore ; Chelation ; Trametes versicolor ; Biosolubilization ; Leonardite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A heat stable, low molecular weight (〈1000) extracellular product inTrametes versicolor (=Coriolus versicolor=Polyporous versicolor) cultures was demonstrated to be a principal factor in the solubilization of leonardite and other low-rank coals. The solubilization of leonardite byT. versicolor cell-free cultures and active fractions was inhibited by Fe3+ and was mimicked by the siderophore desferal mesylate and the iron chelating agents EDTA and 8-hydroxyquinoline. Leonardite solubilization by these later compounds was also inhibited by Fe3+. The ferrated and unferrated form of the partially purified active component fromT. versicolor cultures demonstrated absorption spectra that were similar to the ferrated and unferrated form of desferal mesylate.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 10 (1991), S. 138-143 
    ISSN: 1434-9949
    Keywords: Clinical Metrology ; Importance ; Osteoarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seventeen patients with primary osteoarthritis of the knee were evaluated with respect to the severity and clinical importance of pain, stiffness and physical function during the conduct of a double-blind randomized controlled trial of flurbiprofen SR versus diclofenac sodium SR using the WOMAC Osteoarthritis Index. Mean importance scores were similar for items within the same dimension as well as between items in different dimensions. In general, low levels of correlation were noted between the severity and importance of symptoms. Analysis of individual WOMAC items within a given subscale indicated that, although highly correlated, they differed from one another. Factor analysis further supported the contention that scores from items within a subscale could be summated into subscale scores. These observations are of importance in the weighting and aggregation of items within discrete dimensions and have the potential for reducing sample size requirements for clinical trials in osteoarthritis.
    Type of Medium: Electronic Resource
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