ISSN:
1432-0428
Keywords:
Non-obese diabetes-prone mouse
;
cyclophosphamide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cyclophosphamide promoted the onset of overt diabetes in non-obese diabetes-prone mice of both sexes. Two injections of this agent at 2 weeks apart were necessary to obtain a constant high incidence, although even a single injection was effective in some animals. Clinical symptoms of the cyclophosphamide-induced diabetes were similar to those of the naturally occurring type. The same schedule of cyclophosphamide treatment failed to induce diabetes in non-diabetic mouse strains, such as DS/Shi, Jcl: ICR or in non-obese non-diabetes-prone mice, which suggests that the promotion of diabetes by cyclophosphamide in non-obese diabetes-prone mice is not due to the simple pharmacological action of this agent but to some immunopharmacological action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00276978
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