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  • Articles: DFG German National Licenses  (2)
  • 1985-1989  (2)
  • 201Tl  (1)
  • Cardiomyopathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. S66 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; 11C-palmitate ; Cardiomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258110
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diagnostic value of early and delayed 201Tl thyroid scintigraphy in the evaluation of cold nodules for malignancy (1986)
    Springer
    European journal of nuclear medicine 11 (1986), S. 413-416 
    Details
    ISSN: 1619-7089
    Keywords: 201Tl ; Thyroid nodules ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed 201Tl thyroid scintigraphy using an early and delayed scanning technique in 34 patients exhibiting cold nodules on 99mTc scans. Of the 29 benign nodules, 27 were correctly diagnosed as being negative, i.e. 93% specificity. However, two of five malignant nodules failed to concentrate activity on both the early and delayed scans. The low sensitivity (60%) of this method for detecting carcinomas limits its clinical value in the routine, diagnostic work-up of patients with suspected thyroid cancer. Our findings are in contrast to previous more optimistic reports.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261001
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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