ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Disturbed function of the pineal gland in familial amyloid polyneuropathy (1987)

Higa, S. ; Suzuki, T. ; Sakoda, S. ; [et al.]

Springer

Journal of neural transmission 69 (1987), S. 97-103

add to mindlist on the mindlist

Details

ISSN: 1435-1463

Keywords: Pineal gland ; familial amyloid polyneuropathy ; 6-hydroxymelatonin ; metanephrine ; normetanephrine

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In order to estimate the function of the pineal gland, the sympathetic nervous system and the adrenal medulla in patients with familial amyloid polyneuropathy relative to healthy subjects, we have quantified urinary 6-hydroxymelatonin, normetanephrine and metanephrine. Urinary 6-hydroxymelatonin level correlated with neither of two O-methylated catecholamine levels in healthy subjects. The excretion of both 6-hydroxymelatonin and metanephrine were reduced in the patient group as compared with the control group, and the normal daily rhythm of 6-hydroxymelatonin was undetectable in the most of the patients. This finding indicates that the function of the pineal gland is disturbed in familial amyloid polyneuropathy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01244100

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Determination of metabolites relating to the tryptophan-NAD pathway in rat urine by cellulose high performance thin-layer chromatography (1985)

Yamada, M. ; Minami, Y. ; Yuyama, S. ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 8 (1985), S. 69-72

add to mindlist on the mindlist

Details

ISSN: 0935-6304

Keywords: Thin-layer chromatography, HPTLC ; Cellulose plates ; Tryptophan-NAD pathway ; Rat urine ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: High performance thin-layer chromatography (HPTLC) was used to determine 12 metabolites of the tryptophan-NAD pathway in rat urine. The method of separation described in the previous report was improved. The metabolites were separated on the cellulose plate by using five multiple developments with four solvent systems. The plate was scanned by the TLC scanner at 254 nm and the amounts of the metabolites were calculated by comparing peak areas of the scanning curves obtained for the urine sample and for the authentic standards. This procedure can be used as a semiquantitative determination method for the metabolites in biological fluids.

Additional Material: 1 Ill.