ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A novel, mildly antibacterial, α-bromoenone (7-bromocavernicolenone) has been isolated from the Mediterranean sponge Aplysina (= Verongia) cavernicola. Its structure, 7-bromo-1,5-dihydroxy-2-azabicyclo[3.3.1]non-6-en-3,8-dione (3), is based on X-ray and NMR analysis and on the observation that acetylation of 3 affords two monoacetates. An unprecedented phenol oxidative biogenetic pathway is suggested leading to 7-bromocavernicolenone via 3-bromotyrosine and 5-bromodopa.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19850680536
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