ISSN:
1432-1076
Keywords:
Autoimmune neutropenia
;
High-dose immunoglobulin therapy
;
Antineutrophil autoantibodies
;
Flow cytometry neutrophil-bound IgG
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract High-dose immunoglobulin (HD-Ig) therapy was given to an infant with autoimmune neutropenia (AIN), and antineutrophil autoantibodies (ANAA). The patient's absolute neutrophil count in peripheral blood increased from 300/ mm3 to 3000–4000/mm3 7 days after treatment. Although the neutrophil count gradually decreased thereafter, transient increases were observed after each single booster infusion repeated at 3-week intervals. By continuing this treatment, clinical symptoms were markedly alleviated, and the patient's susceptibility to infection was reduced. The increase in neutrophils showed a positive correlation with the increase in serum IgG, and with the increase in the ratio of T helper/T suppressor cells. The neutrophil-bound IgG level and serum lysozyme level were decreased after HD-Ig therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00444951
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