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  • Articles: DFG German National Licenses  (11)
  • 1980-1984  (2)
  • 1965-1969  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of cytokeratins in endocrine cells of the human pituitary gland and in pituitary, adenomas (1984)
    Springer
    Virchows Archiv 404 (1984), S. 359-368 
    Details
    ISSN: 1432-2307
    Keywords: Immunohistochemistry ; Pituitary gland ; Pituitary adenomas ; Cytokeratins ; Intermediate filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten non-neoplastic pituitary glands and 22 pituitary adenomas producing different hormones were studied by immunofluorescence microscopy as well as peroxidase-antiperoxidase and biotin-avidin techniques on frozen sections and formalin-fixed, paraffin-embedded material using antibodies to cytokeratin, vimentin, GFAP, neurofilament protein and different pituitary hormones. The endocrine cells in non-neoplastic pituitary glands as well as in most pituitary adenomas were cytokeratin-positive. The cytoplasmic cytokeratin distribution patterns of non-neoplastic and tumor cells were similar and typical of the type of hormone produced: GH-producing normal cells showed a paranuclear condensation of cytokeratin-reactive intermediate filaments; this accumulation was even further accentuated in GH-producing adenomas resulting in fibrous bodies (Kovacs and Horvath 1978) decorated by cytokeratin antibodies. Prolactin-producing cells showed a less intense cytoplasmic cytokeratin-specific staining with focal paranuclear accentuation in non-neoplastic as well as in neoplastic glands. ACTH-producing cells in normal pituitary glands as well as in adenomas exhibited a strong and more uniform cytoplasmic cytokeratin staining. The cytokeratin reactivity in glycoprotein hormone-producing cells of non-neoplastic tissue and adenomas was weak. Vimentin and GFAP reactivity was confined to agranular folliculo-stellate cells. The specific and different distribution patterns of cytokeratins in pituitary cells can, therefore, provide an (indirect) indication to the production of a specific hormone if immunocytochemistry fails to demonstrate hormone production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695220
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  • 2
    Electronic Resource
    Electronic Resource
    Die experimentelle Frühsommer-Encephalomyelitis (FSEM) der weißen Maus (1966)
    Springer
    Acta neuropathologica 7 (1966), S. 162-174 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The present investigation deals with the topography of brain lesions in albino mice as consequence of subcutaneous infection with spring-summer-encephalitisvirus (strains VIE 415 B, V 175, HYPR and WILL). The lesions could be located preferably in the cortex, nucleus lentiformis, some nuclei of the thalamus- such as nucleus parataenalis, centralis, paracentralis, the zona incerta and the nucleus reticularis-, the formatio reticularis and the trigeminal and vestibular region. Cellular infiltration were most often found along the borders of these nuclei, respectively in their rostral or ventral parts. Similar infiltrations were found in fibertracts of adjacent regions. The experimental spring-summer-encephalomyelitis in albino mice apparently leads to spotted perivascular alterations of gray and white matter as well.
    Notes: Zusammenfassung In der vorliegenden Arbeit wurde die Topik der Hirnläsionen nach einer experimentellen subcutanen Infektion der Maus mit FSEM-Viren der Stämme VIE 415 B, V 175,Hypr undWill beschrieben. Die bevorzugten Lokalisationen der Encephalitis waren die Großhirnrinde, der Linsenkern, einige Thalamuskerne (Nucl. parataenalis, Nucl. centralis, Nucl. paracentralis, Zona incerta), die Formatio reticularis und die Trigeminus- und die Vestibulariskerngebiete. Eine weitere Praedilektionsstelle für das Auftreten encephalitischer Infiltrate waren die Grenzregionen zwischen den einzelnen Kernen. Die rostralen und die ventralen Hirnabschnitte waren bevorzugt befallen. Auch einige Fasersysteme zeigten entzündliche Veränderungen. Bei der durch das FSEM (CEE)-Virus hervorgerufenen Encephalitis handelt es sich um eine fleckförmige Encephalitis mit perivasculären Gewebsalterationen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686782
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Entwicklung des morphologischen Bildes der experimentellen FSEM (Frühsommer-Encephalomyelitis) der weißen Maus (1966)
    Springer
    Acta neuropathologica 7 (1966), S. 62-69 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Alteration of the CNS in albino mice infected with spring-summer-encephalitis-virus were investigated at different intervals after infection. 4 stages of the disease could be differentiated histologically: 1. Dilatation of blood vessels, proliferation of endothelium cells, pyknosis of Purkinje-cells and the motoric cells of the spinal cord. 2. Infiltrations in the basal parts of the meninges, the formatio reticularis, the ventral part of the septum pellucidum and the nucleus ventralis thalami, which may be found nearly simultaneously. 3. A rapidly spreading meningitis while the intensity of the encephalitis remains unchanged. 4. Increasing severity of encephalitis without any further change of the meningeal infiltrations. 0
    Notes: Zusammenfassung In der vorliegenden Arbeit wird über Befunde berichtet, die bei subcutan mit FSEM (=CEE)-Virus-haltigen Gehirnsuspensionen verschiedener Verdünnungsstufen infizierten Mäusen zu verschiedenen Zeitpunkten post infectionem erhoben werden konnten. In der Entwicklung der FSEM der Maus konnten folgende Stadien deutlich differenziert werden: 1. Reizzustand des ZNS. 2. Fast gleichzeitiges Auftreten einer Infiltration der Meningen vor allem basal und einer perivasculären Infiltration in einigen Regionen des ZNS. 3. Rapide Zunahme der Meningitis ohne Intensitätsveränderungen der encephalitischen Läsionen. 4. Keine Zunahme der meningitischen Veränderungen und Intensivierung der Encephalitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686609
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  • 4
    Electronic Resource
    Electronic Resource
    Die Neuropathologie der durch Langat-Virus bedingten Encephalomyelitis der weißen Maus (1969)
    Springer
    Acta neuropathologica 12 (1969), S. 158-172 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Encephalitis ; Langat Virus (TP 21) ; Arbo-Encephalitides ; Polio-Encephalomyelitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Topik und Histologie der Hirnläsionen nach experimenteller subcutaner Infektion der weißen Maus mit Langat-Virus (TP 21) wurden untersucht. Zwei Verlaufsformen der Erkrankung konnten bei den Tieren festgestellt werden: eine Gruppe erlag unter Lähmungserscheinungen bis zum 12. Tag post infectionem, die andere Gruppe überlebte. Histologisch ist dieakute Langat-Encephalomyelitis eine herdförmige Polio-Encephalitis mit Parenchymnekrosen und Beteiligung der Meningen und des Plexus. Bei derinapparenten Verlaufsform treten granulomartige Gliaproliferationen in der grauen Substanz sowohl perivasculär als auch unabhängig vom Gefäßsystem auf. Die Encephalitis zeigt eine Prädilektion im Linsenkern, in der Substantia nigra, im Pallidum, im ventralen Thalamuskern, in den Kleinhirnkernen und in der Formatio reticularis. Außerdem sind der Cortex, der Vestibularis- und der Trigeminuskern betroffen. Die Topik der Läsionen ist bei der akuten und inapparenten Form gleich. Auf Grund der Läsionsart und der Läsionstopik lassen sich die durch Langat-Virus und die durch Frühsommer-Encephalomyelitis-Virus hervorgerufenen Encephalitiden bei der Maus eindeutig unterscheiden.
    Notes: Summary The pattern and histopathology of cerebral lesions after experimental subcutaneous infection with Langat virus (TP 21) of the white mouse were examined. Two types of course of the illness were observed: one group of animals suffering from paralyses died up to the 12th day after infection, the other group survived. Histologically, acute Langat-encephalomyelitis is a focal polio-encephalitis with parenchyma necroses and affection of the meninges and plexus. In inapparent forms, granuloma-like glial proliferation in the white matter is seen perivascularly as well as without relation with the vascular system. The encephalitis shows predilective affection of the lentiform nuclei, substantia nigra, pallidum, ventral thalamus, cerebellar nuclei and formatio reticularis. In addition, the cerebral cortex and the vestibular and trigeminal nuclei were affected. The topic pattern of the lesions is the same in acute and inapparent forms. Concerning the nature and pattern of the lesions, encephalitis caused by Langat virus and the virus of Spring-Summer-Encephalitis in mice are easily to be differentiated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692503
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemistry of folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas (1984)
    Springer
    Acta neuropathologica 65 (1984), S. 35-40 
    Details
    ISSN: 1432-0533
    Keywords: Immunohistochemistry ; Folliculo-stellate cells ; Pituitary gland ; Pituitary adenoma ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Presence and distribution of S-100 protein (S-100), neuron-specific enolase (NSE), cytokeratin polypeptides, glial fibrillary acidic protein (GFAP), vimentin, actin, lysozyme and pituitary hormones (prolactin, hGH, ACTH, β-FSH, β-LH, β-TSH, alpha subunit) in folliculo-stellate cells (FSC) were studied in seven normal human pituitary glands and 28 pituitary adenomas using peroxidase-antiperoxidase and the avidin-biotin immunohistochemical techniques. Approximately 5% of the cells of the adenohypophysis were agranular, non-hormon-producing FSC most of which showed a conspicuous and strong reaction with S-100 antibodies but some were, in addition, GFAP- and vimentin-positive. In contrast to endocrine cells (EC), FSC were not decorated by antibodies to NSE or cytokeratins. In addition to supportive functions, these cells, due to their close special relationship to EC, seem to have transport and other metabolic functions yet to be elucidated. By their S-100 reactivity and their distribution FSC are comparable to glial cells of the central and schwann and satellite cells of the peripheral nervous system (PNS) as well as to supportive cells in neuroendocrine organs and related tumors (e.g., pheochromocytomas, paragangliomas, carcinoids). With one exception, S-100 reactive FSC were not found in pituitary adenomas. The immunohistochemical demonstration of S-100 protein in pituitary tissue is, therefore, a reliable aid in the discrimination between adenomas and normal pituitary tissue, particularly in small and poorly preserved specimens. In one adenoma FSC were found in addition to ACTH-producing tumor cells. This seems to be an extremely rare event suggesting a combination tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689825
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  • 6
    Electronic Resource
    Electronic Resource
    Verhaltensänderung und Neuropathologie bei der 3-Acetylpyridinvergiftung der Ratte (1968)
    Springer
    Acta neuropathologica 10 (1968), S. 34-44 
    Details
    ISSN: 1432-0533
    Keywords: 3-acetylpyridine intoxication ; Inferior olives ; Experimental brain lesions ; Behavioural changes ; Disorders of learning ; Impairment of gait
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verhaltensänderungen und die Neuropathologie bei der 3-Acetylpyridinvergiftung der Ratte werden beschrieben. Im Gegensatz zu den Angaben in der Literatur führt bei Ratten die Verabfolgung der Dosis letalis 50 von 3-Acetylpyridin zu einem totalen bis subtotalen Ausfall der unteren Oliven. Dementsprechend lassen sich die aufgetretenen und durch einen Test quantitativ erfaßten Gangstörungen als Folge einer Olivenschädigung interpretieren. Die ebenfalls beobachteten Lernstörungen können neuropathologisch nicht eindeutig geklärt werden. Die morphologischen Befunde werden in Hinblick auf die Pharmakologie des 3-Acetylpyridins diskutiert.
    Notes: Summary Changes in behaviour and the neuropathological feature in rats following intoxication with 3-acetylpyridine are described. In contrast to the data in the literature, the administration of the dosis letalis 50 of 3-acetylpyridine to rats resulted in a total to subtotal lesion of the inferior olives. Disorders in gait that were observed and also quantitatively measured in these animals can be interpreted as a consequence of the lesion of the olives. Disorders of learning, also observed in treated rats, cannot be explained from the neuropathological findings. The morphological findings are discussed in respect to the pharmacology of 3-acetylpyridine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690508
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  • 7
    Electronic Resource
    Electronic Resource
    Immunofluoreszenzuntersuchungen über den Ablauf der Grippevirusvermehrung in der Mäuselunge (1966)
    Springer
    Archives of virology 18 (1966), S. 244-252 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The fate of not mouse adapted influenza virus in the mouse lung was investigated by immunofluorescence methods. The replication of the non adapted virus, which starts just like that of the adapted virus in the alveolar epithelia at the transition from the bronchioles to the alveolar sacs, begins considerably later than after infection with adapted virus. It is at a maximum at about 10 hours p.i. and then subsides. The virus release by the cells is much slower. Neither the bronchioles nor the bronchi or the trachea are involved. Even after 8 days p.i. some isolated alveolar cells show some fluorescence indicating virus release.
    Notes: Zusammenfassung Das Schicksal von nicht mausadaptiertem Influenzavirus in der Mäuselunge wurde unter Anwendung der Immunofluoreszenztechnik untersucht. Die Virusreplikation, die ebenso wie beim adaptierten Virus in den Alveolarepithelzellen im Übergangsbereich vom Bronchulus zum Saccus alveolaris beginnt, setzt wesentlich später ein als nach Infektion mit adaptiertem Virus, erreicht etwa 10 Stunden post infectionem ihr Maximum und klingt dann wieder ab. Die Virusausschleusung aus der Zelle erfolgt wesentlich langsamer. Weder die Bronchiolen noch die Bronchien und die Trachea werden befallen. Noch 8 Tage post infectionem finden sich einzelne infizierte Alveolarepithelzellen, die offenbar Virus abgeben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01241845
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  • 8
    Electronic Resource
    Electronic Resource
    Immunofluoreszenzuntersuchungen über den Ablauf einer intranasalen Grippeinfektion bei immunisierten Mäusen (1966)
    Springer
    Archives of virology 18 (1966), S. 294-303 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The behaviour of mouse-adapted influenza virus (A2-Asia-Wien 83/M) in the lung of immune mice was investigated after intranasal infection. The replication did not differ appreciably from that in a non-immune animal up to 10 hours post infectionem. Fluorescent material was noted in the bronchi, but this was not accompanied by destruction of bronchial epithelium. From the 8th to 10th hour onward a rapid decrease of the virus replication was seen.
    Notes: Zusammenfassung In der vorliegenden Arbeit wurde das Verhalten von intranasal eingebrachtem mausadaptiertem Grippevirus (A2-Asia-Wien 83/M) in der Lunge immuner Mäuse untersucht. Die Vermehrung unterschied sich bis 10 Stunden post infectionem nur wenig von derjenigen im nicht immunisierten Organismus. Vor allem kam es auch zu einer Bronchialfluoreszenz, die aber nicht mit einer Zerstörung des Bronchialepithels einherging. Ab der 8. bis 10. Stunde post infectionem kam es zu einer raschen Verminderung der Virusreplikation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250143
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  • 9
    Electronic Resource
    Electronic Resource
    Immunofluoreszenzuntersuchungen über den Ablauf der Grippevirusvermehrung in der Mäuselunge (1965)
    Springer
    Archives of virology 17 (1965), S. 641-653 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The experimental influenza pneumonia of the mouse has been investigated with fluorescent antibody against influenza A2 virus. Contrary to the histopathologic findings but in accordance with the situation found in psittacosis, the virus replication starts at the transition from the bronchiole to the alveolar sac. It spreads first to the surrounding alveolar epithelium and considerably later to the bronchi.
    Notes: Zusammenfassung Die experimentelle Grippepneumonie der Maus wurde unter Anwendung der Immunofluoreszenztechnik untersucht. Es ergab sich, daß die Virusreplikation bei Grippe im Gegensatz zu den pathohistologisch feststellbaren Veränderungen, übereinstimmend aber mit Befunden bei Psittakose, im Übergangsbereich vom Bronchulus zum Saccus alveolaris beginnt, zuerst auf die umgebenden Alveolarepithelien und erst wesentlich später auf die Bronchien übergreift.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01262240
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  • 10
    Electronic Resource
    Electronic Resource
    Grippeinfektion bei mit Tusche vorbehandelten Mäusen (1966)
    Springer
    Archives of virology 18 (1966), S. 445-451 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The influence of an intravenous injection of india ink on a subsequent infection with influenza A2 virus (strain Vienna 83/M) in white mice was investigated. The same lung suspension was about five times more effective in treated animals than in the controls. Moreover, the virus titer in the liver of treated animals was significantly higher. In none of the animal groups any antibody could be titrated in the serum until death. There was no difference in interferon content of the liver between india ink treated and control mice.
    Notes: Zusammenfassung In der vorliegenden Arbeit wurde der Einfluß einer intravenösen Tuschegabe auf eine nachfolgende Infektion mit Influenza-A2-Virus (Stamm Wien 83/M) bei weißen Mäusen untersucht. Es erwies sich dabei die gleiche Lungensuspension bei tuschevorbehandelten Tieren als etwa fünfmal wirksamer als bei den unbehandelten Kontrollen. Überdies konnte in der Leber der Tuschetiere ein signifikant höherer Virusgehalt festgestellt werden. Im Serum kam es bis zum Tod der Tiere bei keiner Gruppe zum Auftreten meßbarer Antikörpermengen. Der Interferongehalt der Leber war bei den tuschebelasteten Mäusen und bei den Kontrollen nicht signifikant different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01246576
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