ISSN:
1432-1440
Keywords:
Prajmaliumbitartrate
;
intrahepatic cholestasis
;
Liver (drug effects)
;
Antiarrhythmic agents (adverse effects)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Seven further cases with n-propyl-ajmaliumbitartrate (NPAB)-associated liver damage observed between 1976 and 1980 in two collaborating institutions are reported. The cause/effect relationship could be classified as probable in three cases and as potential in the remaining four patients. No drug rechallenge was carried out. In the clinical management, definite exclusion of biliary tract obstruction had a clear priority over histologic documentation of the degree of the transient liver damage. Follow-up data after 2 years 8 months to 5 years 9 months by personal reinvestigation of three patients and by questionnaire to family physicians and patients in the remaining four cases gave no clinical or serologic indication of persisting or relapsing liver damage. Liver biopsies were not considered to be warranted in the follow-up of these asymptomatic patients with normal liver function tests.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01728432
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