ISSN:
1435-1536
Schlagwort(e):
Copoly (N 5-ω-hydroxyalkyl-L-glutamine-L-glutamic acid)
;
Solvent-induced conformational change
;
pH-induced conformational change
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Maschinenbau
Notizen:
Abstract Copoly (α-amino acid)s consisting ofL-glutamic acid residue andN 5-ω hydroxyalkyl-L-glutamine residue, i.e., 2-hydroxyethyl, 3-hydroxypropyl, and di-2-hydroxyethyl derivatives were prepared by the reactions of copoly (L-glutamic acid) containing succinimide ester with corresponding amino alcohols. The conformation of these copolymers was examined by the CD and infrared measurements. These three copolymers containing about 20–30% hydroxyalkyl groups undergo a methanol-induced and a pH-induced conformational transitions. The copolymer containing about 50% 3-hydroxypropyl group assumes the α-helical conformation in the pH region from 2.5 to 11.6, and in a methanol-water mixture (9∶1). On the other hand, the copolymer containing about 60% di-2-hydroxyethyl groups does not allow any helical conformation even at lower pH and also even in a trifluoroethanol-water mixture (9∶1), suggesting that the branched hydroxyalkyl group is unfavorable for the formation of α-helix. Furthermore, the poly(N 5-di-2-hydroxyethyl-L-glutamine) is shown to have a rather disordered structure in the solid state.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01526625
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