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  • Articles: DFG German National Licenses  (2)
  • 1980-1984  (2)
  • Calcium  (1)
  • absorption  (1)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1980-1984  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Reduced steady-state plasma concentrations of chlorpromazine and indomethacin in patients receiving cimetidine (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 99-102 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; chlorpromazine ; indomethacin ; drug metabolism ; steady-state ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Chronic administration of cimetidine was found to produce a fall in steady-state plasma concentrations of chlorpromazine and of indomethacin in patients. In each case there was some evidence of inhibition of metabolism, suggesting that the mechanism must therefore be decreased absorption sufficient to over-ride the metabolic change. This was confirmed by measurement of excretion of metabolites in the indomethacin study. The fall in indomethacin plasma concentrations was not associated with a change in the clinical effectiveness of the anti-inflammatory therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613934
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Calcium binding activity by chick intestinal brush-border membrane vesicles (1980)
    Springer
    Pflügers Archiv 389 (1980), S. 69-74 
    Details
    ISSN: 1432-2013
    Keywords: Calcium ; Vitamin D ; Intestinal vesicles ; Brush-border membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Uptake of Ca2+ by vesicle preparation of chick intestinal brush-border membranes was rapid and extensive. With tracer quantities of Ca2+ uptake was complete in 10 min whereas with 2.0 mM Ca2+ maximum uptake by the vesicles occurred after one hour incubation. The maximum concentration of Ca2+ found in the vesicles was four times greater than the external Ca2+ concentration showing that the majority of the Ca2+ was membrane bound. The Ca2+ taken up by the vesicles was probably bound to the vesicle's interior since it was not replaced by exposure of loaded vesicles to La3+ (5 mM). The uptake of Ca2+ by the vesicles at different Ca2+ concentrations was analyzed and a high affinity Ca2+ binding site was found with an association constant for Ca2+ of 5×10−5 M. More of these sites were found in the duodenum than the ileum and vitamin D increases the number of these sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587930
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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