ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Acebutolol in hypertension: Relationships between drug concentration and effects (1978)

Martin, M. A. ; Phillips, F. C. ; Tucker, G. T. ; [et al.]

Springer

European journal of clinical pharmacology 14 (1978), S. 383-390

add to mindlist on the mindlist

Details

ISSN: 1432-1041

Keywords: Acebutolol ; N-acetyl metabolite ; drug plasma concentrations ; plasma renin activity ; hypertension ; β-blockade

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Relationships between plasma concentrations of acebutolol (Ac) and its N-acetyl metabolite (Am) and pharmacological effects were studied in patients with essential hypertension. In an acute study (N=7) 400 mg oral acebutolol produced similar peak plasma levels of Ac and Am but Am had a longer half life. Group mean pulse and blood pressure fell significantly, although the size of individual blood pressure fall varied five-fold. There was no significant change in plasma renin activity. Correlations were found between drug concentration and β-blockade, assessed as % reduction in exercise tachycardia, and between both of these and the fall in post exercise systolic blood pressure. Similar comparisons were made in a chronic optimum dose study (N=11) both pre-dose and three hours post-dose. Am concentration was consistently higher than Ac at both times. Blood pressure was lowered equally pre-and post-dose when compared to placebo and plasma renin activity (PRA) was reduced on active treatment. Correlations were again shown between drug concentrations and β-blockade but none were found with changes in blood pressure or PRA. Between subject differences in blood pressure response could not be fully explained in terms of the other measurements but it is unlikely that pharmacokinetic differences are the major source of this variability.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00716378

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Oxidation der Pb-Ca-Legierungen in flüssigem Zustand (1978)

González, J. A. ; Martín, M. ; Feliu, S.

Weinheim [u.a.] : Wiley-Blackwell

Materials and Corrosion/Werkstoffe und Korrosion 29 (1978), S. 815-820

add to mindlist on the mindlist

Details

ISSN: 0947-5117

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Description / Table of Contents: Oxidation of PbCa alloys in the liquid stateThe effect of various temperatures, the composition of the alloy and the corroding atmosphere is studied with a thermobalance during the oxidation of molten PbCa alloys. The rate controlling step of the oxidation depends on the test conditions. The results obtained at 700°C are in agreement with data found in literature and according to which the oxidation increases with the Ca content; in this range calcium is subject to preferential oxidation. At 600°C and temperatures below that the addition of calcium does not only not increase oxidation but may give rise to a decrease.

Notes: Mit einer Thermowaage wird die Wirkung verschiedener Temperaturen, der Zusammensetzung der Legierung und der Zusammensetzung der angreifenden Atmosphäre bei der Oxidation geschmolzener Pb-Ca-Legierungen untersucht. Der geschwindigkeitsbestimmende Schritt der Oxidation hängt von den Versuchsbedingungen ab. Bei 700°C bestätigen die bei der vorliegenden Untersuchung erhaltenen Ergebnisse die Literaturangaben, wonach die Oxidation bei zunehmendem Ca-Gehalt ansteigt; dabei wird das Calcium vorzugsweise oxidiert. Dagegen wird bei 600°C und darunter die Oxidation durch Zusatz von Calcium nicht nur nicht verstärkt, sondern sogar verringert.

Additional Material: 11 Ill.