Electronic Resource
Springer
Cellular and molecular life sciences
31 (1975), S. 1048-1049
ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The membrane potential in guinea-pig's papillary muscles from right ventricle was recorded by glass microelectrodes and stimulation was effected by current pulses applied through a sucrose-gap. Action potentials with overshoot were recorded in the solution lacking Na+ and Ca++ but containing 2–95 mM Mn++. The overshoot was inecease with the increased of [Mn++]o by about 30 mV/decade. Similar Mn++-dependent action potentials were also obtained in Na-free solution containing 0.6 mM Ca++. The results indicate that Mn inward current is sufficient to generate action potentials in cardiac muscle.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02326952
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