ZIB

Digitale Medien

Reduction of nitrate by monomeric molybdenum(V) complexes in dimethylformamide (1979)

Taylor, R. D. ; Todd, P. G. ; Chasteen, N. D. ; [weitere]

s.l. : American Chemical Society

Inorganic chemistry 18 (1979), S. 44-48

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ISSN: 1520-510X

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/ic50191a008

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Digitale Medien

DETERMINATION OF PUNGENCY DUE TO CAPSICUM BY GAS-LIQUID CHROMATOGRAPHY (1977)

TODD, P. H. ; BENSINGER, M. G. ; BIFTU, T.

Oxford, UK : Blackwell Publishing Ltd

Journal of food science 42 (1977), S. 0

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ISSN: 1750-3841

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: A method is described for determining the pungency, due to capsaicinoids, in raw spices, extracts, food and pharmaceutical products by means of GLC. Pure samples of the individual capsaicinoids were prepared and their pungencies determined by ASTA method 21.0 (Scoville Heat Test). The threshold pungency values for these materials are presented. The pure capsaicinoids were used to quantitate the GLC method and identify capsaicinoids found in natural materials. Details concerning sample preparation and silylation are discussed for various types of samples. By combining the concentration and threshold pungency of the individual capsaicinoids, the Scoville pungency of the material can be determined. Comparative data for pungency determined organolyptically and by GLC on samples ranging from 50,000–2,000,000 Scoville gave a correlation coefficient of 0.95 for raw data over a 1-yr period.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2621.1977.tb12573.x

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Digitale Medien

Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics (1978)

Nattrass, M. ; Todd, P. G. ; Turnell, D. ; [weitere]

Springer

Diabetologia 14 (1978), S. 389-395

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ISSN: 1432-0428

Schlagwort(e): Phenformin ; sulphonylureas ; blood glucose ; lactate ; pyruvate ; ketone bodies ; alanine ; glycerol ; non-esterified fatty acids ; growth hormone ; gluconeogenesis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Twelve hour metabolic rhythms have been determined in two groups of subjects during combined therapy with a sulphonylurea and phenformin 50 mg twice daily. Subjects with clinical evidence of complications of diabetes showed greater abnormalities in concentrations of blood intermediary metabolites than a group of subjects without complications despite similar mean blood glucose concentrations in the two groups (7.6 mmol/l with complications; 7.3 mmol/l without complications). Mean blood lactate (1.93 mmol/l v 1.39 mmol/l), alanine (0.56 mmol/1 v 0.43 mmol/l), total blood ketone bodies (0.20 mmol/l v 0.14 mmol/l) and several other intermediary metabolites and their ratios were significantly higher in the group with diabetic complications. It is suggested that the differences between the two groups may arise from impaired disposal of phenformin leading to higher blood concentrations in the group with diabetic complications, despite normal liver function tests and plasma creatinine concentration. It is probable that this accumulation of phenformin results in more pronounced effect upon blood glucose and other intermediary metabolites. Thus, the metabolic abnormalities previously reported in patients treated by phenformin alone are also present during combined sulphonylurea and phenformin therapy, and in the presence of diabetic microangiopathy these abnormalities are accentuated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01228133

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Digitale Medien

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics (1977)

Nattrass, M. ; Todd, P. G. ; Hinks, L. ; [weitere]

Springer

Diabetologia 13 (1977), S. 145-152

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ISSN: 1432-0428

Schlagwort(e): Phenformin ; metformin ; glibenclamide ; blood glucose ; lactate ; alanine ; pyruvate ; ketone bodies ; maturity-onset diabetes ; diabetic control ; gluconeogenesis ; glycerol ; insulin ; triglycerides ; growth hormone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00745143

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Digitale Medien

Ultrastructure of the spermatozoa and spermiogenesis in New Zealand freshwater eels (Anguillidae) (1976)

Todd, P. R.

Springer

Cell & tissue research 171 (1976), S. 221-232

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ISSN: 1432-0878

Schlagwort(e): Spermiogenesis ; Sperm ultrastructure ; Anguillidae ; Morphometrics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The spermiogenesis and sperm ultrastructure of Anguilla australis schmidtii and A. dieffenbachii is described. During spermiogenesis the chromatin material condenses into the crescent-shaped head of the mature sperm. By elongation of the sperm head the mitochondrion is displaced to the anterior of the head remote from the posterior centriolar apparatus. A ciliary rootlet becomes segregated during spermiogenesis to form a membrane covered, striated, rod-like appendage. From the proximal centriole arise two sets of filaments, each containing three subfibrils. One group of five filaments extends anteriorly along the inner concave side of the head. A group of four modified filaments pass along the outer, convex, side. The middle subfibril B of each triplet in the group of four filaments is flattened and joins the two subfibrils A and B, forming a binocular shaped structure. The motile flagellum has a 9 + 0 axonemal pattern.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00219407

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