ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
3-Hydroxy-ceph-3-em-esters 5 a-c, versatile intermediates for the preparation of new β-lactam antibiotics, were obtained by ozonolysis of the corresponding 3-methylidene-esters 3 a-c. Reduction and elimination gave the 3-unsubstituted ester 13; derivatives 16 a-c and 20-22 resulted from O-alkylation. The 3-methoxy-esters 16 a-c were converted into the corresponding acids 23 a-d. Several other transformations of the β-ketoester system are described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19740570705
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