ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Weanling male mice of strain C57B1. were fed a lard-enriched diet for periods of 1, 4, 7, 10, 14, or 28 days. Beginning during the second week of consumption of this ration, articular chondrocytes of the femoral heads were increased in number and size and showed ultrastructural changes. The latter manifested themselves in nuclear enlargement, intensification of organellar development and in acceleration of regression. There was no evidence of abnormal deposition of lipid material within the chondrocytes beyond that due to organellar disintegration. It was concluded that the early effects of a lard-enriched diet on articular cartilage consist of an overall stimulation of cell function followed by premature exhaustion. The primary site of action of the dietary fat remains unknown.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091660304
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