ISSN:
1432-1912
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Perseitol heptanitrate, prepared by nitration of the 7 carbon heptanol, perseitol, extracted from the seed of the Mexican avocado, was compared with other organic nitrates in its action on the coronary circulation of dogs. When injected into the coronary circulation of isolated hearts perfused from a donor dog, or of hearts prepared in situ, its coronary dilator action was qualitatively similar to the effects of nitroglycerin, mannitol hexanitrate, and pentaerythrityl tetranitrate. Upon intravenous injection, the longer chain nitrates were from 8 to 15 times less active than nitroglycerin in their effects upon coronary flow and arterial pressure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00246351
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